Detection of structural changes of nucleic acids under the action of 2\',5\'-oligoadenylates

Tkachuk, Z. Yu.; Kozlov, A. V.; Tkachuk, L. V.; Phylozop, T. I.; Mikhailopulo, I. A.

doi:10.7124/bc.0003E4

Biopolym. Cell. 1995; 11(2):82-87.

http://dx.doi.org/10.7124/bc.0003E4

Detection of structural changes of nucleic acids under the action of 2',5'-oligoadenylates

1Tkachuk Z. Yu., 1Kozlov A. V., 1Tkachuk L. V., 2Phylozop T. I., 2Mikhailopulo I. A.

Institute of Molecular Biology and Genetics, NAS of Ukraine
150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680
Institute of Bioorganic Chemistry, NAS of Belarus
5/2, Kuprevich Str., Minsk, Republic of Belarus, 220141

Abstract

The possibility of certain core 2',5'-oIigoadenylates effect on the structure of nucleic acids was studies in cell culture in vitro. These compounds were shown to induce single-helical regions rise in the structure of nucleic acids using S1 nuclease enzyme. These effects are accompanied by their low penetration into the cells.

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