Some new data concerning the mutagenic action of DNA
DOI:
https://doi.org/10.7124/bc.00039BAbstract
It is shown that spermatozoa of Drosophila melanogaster can transfer molecules of exogenous DNA (or their fragments) from a solution of this DNA injected into the haemocel of an adult male into the ooplasm of the egg. As a result, mutations induced in the descendants arise both in the paternal and the maternal chromosomes obtained by them. The mutagenic effect of exogenous DNA has a prolonged character inducing mutations in the descendants during many cell generations after DNA-treatment of their father. The mechanism of such a prolongation of the mutagenic action of DNA is discussed.References
Gershenson SM, Alexandrov YuN, Malyuta SS. Mutagenic Effect of DNA and viruses in Drosophila. Kiev: Naukova Dumka, 1975; 160 p.
Gershenson SM. Mutagenic action of DNA, insertion, transposition and gene instability. Proc. XIV Int. Congr. of Genet. Moscow: Mir, 1980. V. 1, book 2: 91-115.
Brackett BG, Baranska W, Sawicki W, Koprowski H. Uptake of heterologous genome by mammalian spermatozoa and its transfer to ova through fertilization. Proc Natl Acad Sci U S A. 1971;68(2):353-7.
Lavitrano M, Camaioni A, Fazio VM, Dolci S, Farace MG, Spadafora C. Sperm cells as vectors for introducing foreign DNA into eggs: genetic transformation of mice. Cell. 1989;57(5):717-23.
Siracuso G, Camaioni A, Russ MA et al. Sperm as carrier of foreign DNA. Abs.tr. 12 Int. Meet. ESHRE and ESCO. 1990. Suppl. 34 p.
Fahmy OG, Fahmy MJ. Genetic properties of exogenous deoxyribonucleic acid at various levels of degradation in Drosophila melanogaster. Nature. 1965;207(996):507-10.
Gershenson SM, Zilberman RA, Levochkina OA et al. Evoke mutations in Drosophila melanogaster Timo nucleic acid. Zh Obshch Biol. 1948. 9, No 2: 69-88.
Gershenson SM. Delayed mutagenic effect of DNA in Drosophila. Mechanism of mutation and inducing factors. Praha : Academia, 1965: 291-293.
Mathew C. The production of recessive lethals by calf-thymus dna in Drosophila. Genet Res. 1965;124:163-74.
Khan AH, Alderson T. Mutagenic effect of irradiated and unirradiated DNA in Drosophila. Nature. 1965;208(5011):700–2.
Fahmy OG, Fahmy DJ. Induction of mutations by deoxyribonucleic acid in Drosophila melanogaster. Nature. 1961;191:776-9.
Gerasimova TI. Transposition of mobile elements and their role in insertion mutagenesis in Drosophila. Stability and variability of the genome. Moscow: Nauka. 1985; 26-39.
Green MM. Mobile DNA element and spontaneous gene mutations. Eukaryotic transposable elements as mutagenic agents. New York : Cold. Spring Harbor Lab., 1988: 41-50.
Rubin GM. Dispersed repetitive DNA in Drosophila. Mobile Genetic Elements. New York: Acad, press, 1983: 329-361.
Terracol R. Transcription of rDNA insertions in bobbed mutants of Drosophila melanogaster. Genet Res. 1986;48(3):167-74.
Flavell AJ, Ish-Horowicz D. The origin of extrachromosomal circular copia elements. Cell. 1983;34(2):415-9.
Shiba T, Saigo K. Retrovirus-like particles containing RNA homologous to the transposable element copia in Drosophila melanogaster. Nature. 1983;302(5904):119-24.
Emori Y, Shiba T, Kanaya S, Inouye S, Yuki S, Saigo K. The nucleotide sequences of copia and copia-related RNA in Drosophila virus-like particles. Nature. 1985 Jun 27-Jul 3;315(6022):773-6.
