Influence of α-tocopherol and its derivative on components of liver cell mitochondria membranes during toxic hepatitis

Authors

  • L. B. Bondarenko Institute of Pharmacology and Toxicology of National Medical Academy of Science of Ukraine 14, Eugene Pottier Str., Kyiv, Ukraine, 03057 Author
  • I. S. Blazhchuk Institute of Pharmacology and Toxicology of National Medical Academy of Science of Ukraine 14, Eugene Pottier Str., Kyiv, Ukraine, 03057 Author
  • V. N. Kovalenko Institute of Pharmacology and Toxicology of National Medical Academy of Science of Ukraine 14, Eugene Pottier Str., Kyiv, Ukraine, 03057 Author
  • I. V. Kuzmenko Palladin Institute of Biochemistry, NAS of Ukraine 9, Leontovycha Str., Kyiv, Ukraine, 01601 Author

DOI:

https://doi.org/10.7124/bc.0004F5

Abstract

In experiments on rats (180–250 g b. w.) influence of α-tocoplierol and its derivative on phospholipids, free, esterified and total cholesterol, DPNH-cytochrome c oxidoreductase (complex 1–111 of respiratory chain) of liver cell mitochondria membranes during toxic hepatitis have been studied. It was shown that α-tocopherol and its shortchain derivative in dose 10 mg/kg b. w. could normalise contents of phospholipids and cholesterol and activity of DPNH-cytochrome c oxidoreductase during this pathology.

References

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Published

1998-11-20

Issue

Section

Structure and Function of Biopolymers