Biopolym. Cell. 1991; 7(2):25-72.
Дискуссии
Генная терапия неизбежна, но успеем ли?
1Кордюм В. А.
  1. Институт молекулярной биологии и генетики НАН Украины
    ул. Академика Заболотного, 150, Киев, Украина, 03680

Abstract

Выдвигается и обосновывается положение, согласно которому принятая и единственно возможная модель человеческой цивилизации на обозримое будущее, предусматривающая стабилизацию численности населения с минимальной рождаемостью, является несовместимой с биологией человека в части его генетического аппарата и неизбежно должна привести к генетическому вырождению. С учетом мутагенного давления окружающей среды и практической стабилизации численности населения в развитых странах к генетическому вырождению подошли вплотную или, возможно, в некоторых регионах оно уже происходит. Поскольку повреждения генома, которые уже произошли, потенциально может исправить только генная терапия, ее самое широкое развитие неизбежно, если такое развитие успеют осуществить.

References

[1] Kondrashov AS. Deleterious mutations and the evolution of sexual reproduction. Nature. 1988;336(6198):435-40.
[2] Grinde B. Unhealthy genes. Nature. 1989;338(6210):24.
[3] Finley WH. Radiation as a mutagen. Ala J Med Sci. 1988;25(4):456-9.
[4] Weatherall DJ. Molecular pathology of single gene disorders. J Clin Pathol. 1987;40(9):959-70.
[5] Morley A. Comparison of hprt and HLA-A mutations. Mutat Res. 1989;216(1):72.
[6] Hakoda M, Akiyama M, Kyoizumi S, Awa AA, Yamakido M, Otake M. Increased somatic cell mutant frequency in atomic bomb survivors. Mutat Res. 1988;201(1):39-48.
[7] Tates AD, Rossi AM, Natarajan AT. Detection of hprt- mutants in human T-lymphocytes and mouse splenocytes. Mutat Res. 1989;216(1):83–4.
[8] Den Otter W, Koten JW, Derkinderen DJ. A new model for oncogenesis. From tumour immunology to a mathematical approach of oncogenesis. Anticancer Res. 1986;6(3 Pt B):509-14.
[9] Hood L. Biotechnology and medicine of the future. JAMA. 1988;259(12):1837-44.
[10] Tepperman J, Tepperman HM. Metabolic and Endocrine Physiology. 5th ed. Year Book Medical Publishers Inc., Chicago, IL. 1987;
[11] Speed RM. The possible role of meiotic pairing anomalies in the atresia of human fetal oocytes. Hum Genet. 1988;78(3):260-6.
[12] Templado C, Benet J, Genesc? A, Navarro J, Caballin MR, Mir? R, Egozcue J. Human sperm chromosomes. Hum Reprod. 1988;3(2):133-8.
[13] Mikamo K, Kamiguchi Y, Tateno H. Spontaneous and in vitro radiation-induced chromosome aberrations in human spermatozoa, application of a new method. Environ Mol Mutagen. 1989; 14, Suppl:129.
[14] Martin RH. Segregation analysis of translocations by the study of human sperm chromosome complements. Am J Hum Genet. 1989;44(4):461-3.
[15] VOLPE EP. Developmental Biology and Human Concerns. Am Zool. 1987;27(2):697–714.
[16] Edwards RG. Causes of early embryonic loss in human pregnancy. Hum Reprod. 1986;1(3):185-98.
[17] McKusick V. Mendelian inheritance in man. VIII edn. Baltimore; London: The Johus Hopkins Univ. press, 1988:1626.
[18] Sampson JR, Scahill SJ, Stephenson JB, Mann L, Connor JM. Genetic aspects of tuberous sclerosis in the west of Scotland. J Med Genet. 1989;26(1):28-31.
[19] Czeizel A, Kis-Varga A. Mutation surueillance of sentinel anomalies in Hungaryr 1980-1984. Biol. Zbl. 1988; 107(4):447-53.
[20] Marx JL. A parent's sex may affect gene expression. Science. 1988;239(4838):352-3.
[21] Renard JP, Barra J, Babinet C. Action of the paternal genome at the beginning of embryonic development. Reprod Nutr Dev. 1988;28(6B):1541-54.
[22] Baranov VS. Chromosome imprinting and regulation of gene expression in early ontogeny of mammals. Izvestiya Sib. otd-niya AN SSSR. Ser. biol. 1989; 2:15-6.
[23] Neri G. Malformazioni fetali da alterazioni dell'assetto genico o chromosomico. Acta Med Rom. 1986;24 (4):403-5.
[24] Czeizel E. Some epidemiological characteristics of Down's syndrome in Hungary. Acta Morphol Hung. 1988;36(1-2):63-77.
[25] Pfeiffer R. A. Die pranatale Selektion der Chromosomenaberrationen beim Menschen. Gynecol Prax. 198; 13(2):225-9.
[26] Galjaard H. Biochemical diagnosis of genetic disease. Experientia. 1986;42(10):1075-85.
[27] Ben-Yoseph Y, Reid JE, Shapiro B, Nadler HL. Diagnosis and carrier detection of Tay-Sachs disease: direct determination of hexosaminidase A using 4-methylumbelliferyl derivatives of beta-N-acetylglucosamine-6-sulfate and beta-N-acetylgalactosamine-6-sulfate. Am J Hum Genet. 1985;37(4):733-40.
[28] Harbers K, Kuehn M, Delius H, Jaenisch R. Insertion of retrovirus into the first intron of alpha 1(I) collagen gene to embryonic lethal mutation in mice. Proc Natl Acad Sci U S A. 1984;81(5):1504-8.
[29] Ginns EI, Tegelaers FP, Barneveld R, Galjaard H, Reuser AJ, Brady RO, Tager JM, Barranger JA. Determination of Gaucher's disease phenotypes with monoclonal antibody. Clin Chim Acta. 1983;131(3):283-7.
[30] Grabowski GA, Dinur T, Osiecki KM, Kruse JR, Legler G, Gatt S. Gaucher disease types 1, 2, and 3: differential mutations of the acid beta-glucosidase active site identified with conduritol B epoxide derivatives and sphingosine. Am J Hum Genet. 1985;37(3):499-510.
[31] DiMauro S, Zeviani M, Bonilla E, Bresolin N, Nakagawa M, Miranda AF, Moggio M. Cytochrome c oxidase deficiency. Biochem Soc Trans. 1985;13(4):651-3.
[32] Yoshida H, Fukui S, Yamashina I, Tanaka T, Sakano T, Usui T, Shimotsuji T, Yabuuchi H, Owada M, Kitagawa T. Elevation of nucleotide pyrophosphatase activity in skin fibroblasts from patients with Lowe's syndrome. Biochem Biophys Res Commun. 1982;107(3):1144-50.
[33] Goodfellow P, Stewart A. Human genetic disease--a new series in TIG. Trends Genet. 1988;4(5):123-4.
[34] Kuglin BKolb H. Fruherkennung des Typ-I-Diabetes: Darstellung und Bewertung vorhandener Ansatze Mitt Dtsch Ges Klin Chem. 1988; 19(1):34-8.
[35] Cavenee WK, Hansen MF. Molecular genetics of human familial cancer. Cold Spring Harb Symp Quant Biol. 1986;51 Pt 2:829-35.
[36] Bookstein R, Lee EY, To H, Young LJ, Sery TW, Hayes RC, Friedmann T, Lee WH. Human retinoblastoma susceptibility gene: genomic organization and analysis of heterozygous intragenic deletion mutants. Proc Natl Acad Sci U S A. 1988;85(7):2210-4.
[37] Lee EY, Bookstein R, Young LJ, Lin CJ, Rosenfeld MG, Lee WH. Molecular mechanism of retinoblastoma gene inactivation in retinoblastoma cell line Y79. Proc Natl Acad Sci U S A. 1988;85(16):6017-21.
[38] Williams RR, Hasstedt SJ, Wilson DE, Ash KO, Yanowitz FF, Reiber GE, Kuida H. Evidence that men with familial hypercholesterolemia can avoid early coronary death. An analysis of 77 gene carriers in four Utah pedigrees. JAMA. 1986;255(2):219-24.
[39] Goldbourt U, Neufeld HN. Genetic aspects of arteriosclerosis. Arteriosclerosis. 1986;6(4):357-77.
[40] Dzharoff L. Hunt for the gene. Za rubezhom. 1989; 1513(28):20.
[41] Diamond JM. AIDS. Infectious, genetic or both? Nature. 1987 Jul 16-22;328(6127):199-200.
[42] Shafran MG, Kolosova NN, Veksler BM. Age features of parameters of blood lipids and their peroxidation in patients with increased genetic risk of developing atherosclerosis. 5th All-Union Congress of Gerontology and pediatricians (Tbilisi, November 22-25, 1988): Proc. ref. of reports. Kyiv, 1988; Ch 2:720-721.
[43] Kruth HS, Comly ME, Butler JD, Vanier MT, Fink JK, Wenger DA, Patel S, Pentchev PG. Type C Niemann-Pick disease. Abnormal metabolism of low density lipoprotein in homozygous and heterozygous fibroblasts. J Biol Chem. 1986;261(35):16769-74.
[44] Mabuchi H, Koizumi J, Shimizu M, Takeda R. Development of coronary heart disease in familial hypercholesterolemia. Circulation. 1989;79(2):225-32.
[45] Kopelovich L. The transformed (initiated) human cell phenotype: study of cultured skin fibroblasts from individuals predisposed to cancer. Mutat Res. 1988;199(2):369-85.
[46] Antonozzi I, Leuzzi V. Hyperargininaemia. J Inherit Metab Dis. 1987;10(2):200.
[47] Wilson JM. Molecular genetics of hypoxanthine-guanine phosphoribosyltransferase deficiency in man. Arch Intern Med. 1985;145(10):1895–900.
[48] Wilson JM, Stout JT, Palella TD, Davidson BL, Kelley WN, Caskey CT. A molecular survey of hypoxanthine-guanine phosphoribosyltransferase deficiency in man. J Clin Invest. 1986;77(1):188-95.
[49] Hasholt L, Wandall A, Soerensen SA. Possible genetic heterogeneity among Danish Fabry patients. Clin Genet. 1989; 35(3):222.
[50] Dunkel G, Scriver CR, Clow CL, Melan?on S, Lemieux B, Grenier A, Laberge C. Prospective ascertainment of complete and partial serum biotinidase deficiency in the newborn. J Inherit Metab Dis. 1989;12(2):131-8.
[51] Theophilus B, Latham T, Grabowski GA, Smith FI. Gaucher disease: molecular heterogeneity and phenotype-genotype correlations. Am J Hum Genet. 1989;45(2):212-25.
[52] Bijman J, De Jonge H, Wine J. Cystic fibrosis advantage. Nature. 1988;336(6198):430.
[53] Blum A, Monnier A. La mortalite en Union Sovietique. Popul et soc. 1988; 223:1-4.
[54] Najean Y. The iatrogenic leukaemias induced by radio- and/or chemotherapy. Med Oncol Tumor Pharmacother. 1987;4(3-4):245-57.
[55] Frolov AF Viruses and their contribution to the gene pool of the human population. Tez. of reports. section genet. aspects of "Man and Biosphere". Kyiv, 1988:127.
[56] L?onard A, Gerber GB, Jacquet P, Lauwerys RR. Carcinogenicity, Mutagenicity, and Teratogenicity of Industrially Used Metals. In: Mutagenicity, Carcinogenicity, and Teratogenicity of Industrial Pollutants. 1984;59–126.
[57] Ulfvarson U, Alexandersson R, Aringer L, Svensson E, Hedenstierna G, Hogstedt C, Holmberg B, Ros?n G, Sorsa M. Effects of exposure to vehicle exhaust on health. Scand J Work Environ Health. 1987;13(6):505-12.
[58] Zapata Gay?n N, Zapata Gay?n C, Gonz?lez Angulo A. Clastogenic changes in the chromosomes of a population of individuals occupationally exposed to different pesticides. Salud Publica Mex. 1987;29(6):506-11.
[59] Ishidate M Jr, Harnois MC, Sofuni T. A comparative analysis of data on the clastogenicity of 951 chemical substances tested in mammalian cell cultures. Mutat Res. 1988;195(2):151-213.
[60] Asta'fev OM, Korchanova NL. Atmospheric air pollution and its effect on the incidence of influenza and acute respiratory tract diseases. Gig Sanit. 1989;(11):42-6.
[61] Nordenson I, Mild KH, Ostman U, Ljungberg H. Chromosomal effects in lymphocytes of 400 kV-substation workers. Radiat Environ Biophys. 1988;27(1):39-47.
[62] Poncelet F, Bogaert MD, Lambotte-Vandepaer M, Meester C. Mutagenicity, Carcinogenicity, and Teratogenicity of Industrially Important Monomers. In: Mutagenicity, Carcinogenicity, and Teratogenicity of Industrial Pollutants. 1984;205–79.
[63] Cantor KP, Hoover R, Hartge P, Mason TJ, Silverman DT, Altman R, Austin DF, Child MA, Key CR, Marrett LD, et al. Bladder cancer, drinking water source, and tap water consumption: a case-control study. J Natl Cancer Inst. 1987;79(6):1269-79.
[64] Meier JR. Mutagenes in chlorinated water. Environ Mol Mutagen. 1989; 14, Suppl:128.
[65] Flessel P, Wang YiY, Kim IS, Chang K. Monitoring for polycyclic aromatic hydrocarbons and mutagens in air particulate matter from Santa Clara county, Cafifornia. Environ Mol Mutagen. 1988; 11(Suppl., N 11):34.
[66] Kamiya A. Study on the behavior of mutagens from municipal incineratobs by means of Ames assay. Environ Mol Mutagen. 1989; 14(Supp b):98.
[67] Crawford WA. On air pollution, environmental tobacco smoke, radon, and lung cancer. JAPCA. 1988;38(11):1386-91.
[68] Gough M. The most potent carcinogen? Resources. 1989; (92):2-5.
[69] Kromhout D. Blood lead and coronary heart disease risk among elderly men in Zutphen, The Netherlands. Environ Health Perspect. 1988;78:43-6.
[70] Ghosh BB, Talukder G, Sharma A. Effects of stannic chloride on human leucocytes in vitro. Cytobios. 1988;56(224):23-7.
[71] Helmi S, El-Seehi M, El-Zyat H, Mostafa MH. Genotoxicity of inorganic mercury. Environ Mol Mutagen. 1989; 14(Suppl):87.
[72] Raj AS, Logan D. Cooperative effects in assays of chemical mixtures of atmospheric pollutants. Environ Mol Mutagen. 1989; 14 :159.
[73] Crow JF. Concern for environmental mutagens: some personal reminiscences. Environ Mol Mutagen. 1989;14 Suppl 16:7-10.
[74] Mathy L, Kampmann W, Higuchi M, Schwartenbeck G, Bartholom? K, Driesel AJ, Grzeschik KH, Olek K. Cystic fibrosis: typing 48 German families with linked DNA probes. Hum Genet. 1987;75(4):359-61.
[75] Stoll C, Dott B, Roth MP, Alembik Y. Birth prevalence rates of skeletal dysplasias. Clin Genet. 1989;35(2):88-92.
[76] Rotter JI, Diamond JM. What maintains the frequencies of human genetic diseases? Nature. 1987 Sep 24-30;329(6137):289-90.
[77] Guttler F. Medical genetics in Denmark. Clin Genet. 1989; 35(3):210-2.
[78] Baird PA, Anderson TW, Newcombe HB, Lowry RB. Genetic disorders in children and young adults: a population study. Am J Hum Genet. 1988;42(5):677-93.
[79] G?ttler F. Diagnosis of inherited metabolic disorders by DNA analysis. Med Lab Sci. 1985;42(4):326-32.
[80] Cekov H. Earth's population - projections in the past and the future. Geografiya. 1988; 42(7):1-4.
[81] Nei M, Saitou N. Genetic relationship of human populations and ethnic differences in reaction of drugs and food. Ethnic. Differ React Drugs Xenobiotics : Proc. Meet. (Titisee, Black Forest, Oct. 3-6, 1985). New York, 1986:21-37.
[82] Seideg?rd J, Pero RW. The genetic variation and the expression of human glutathione transferase mu. Klin Wochenschr. 1988;66 Suppl 11:125-6.
[83] UK team seeks to repair DNA damage. Pract Biotechnol. 1986. 7(9):3.
[84] The feasibility of testing patients for drug acceptance. Eur Biotechnol Newslett. 1988; 44:5.
[85] Spindler SR, Koizumi A, Walford RL, Mote PL. P1-450 and P3-450 gene expression and maximum life span in mice. Mutat Res. 1989;219(2):89-94.
[86] hibuya A, Yoshida A. Frequency of the atypical aldehyde dehydrogenase-2 gene (ALDH2(2)) in Japanese and Caucasians. Am J Hum Genet. 1988;43(5):741-3.
[87] Jeffreys AJ, Royle NJ, Wilson V, Wong Z. Spontaneous mutation rates to new length alleles at tandem-repetitive hypervariable loci in human DNA. Nature. 1988;332(6161):278-81.
[88] Funker H, Frossard PM, Coleman RT, Assmann G. Genetic marker for atherosclerosis at the human insulin gene locus. Am J Hum Genet. 1986; 39(3):A199.
[89] Cherfas J. Geneticists develop DNA finger printing. New Sci. 1985; 105(1449):21.
[90] Berg K. Genetic variation in low density lipoprotein. Beginning of a new era? J Immunogenet. 1985;12(6):263-5.
[91] Mann DM. The pathological association between Down syndrome and Alzheimer disease. Mech Ageing Dev. 1988;43(2):99-136.
[92] Sheridan R, Llerena J Jr, Matkins S, Debenham P, Cawood A, Bobrow M. Fertility in a male with trisomy 21. J Med Genet. 1989;26(5):294-8.
[93] Muller-Wiedermann H. Schwangerschaftsabbruch bei genetischer indication. Gynecol Prax. 1989; 13(2):315-20.
[94] Donlan MA, Dolan CR. Ring chromosome 18 in a mother and son. Am J Med Genet. 1986;24(1):171-4.
[95] Zlotogora J, Sagi M, Zeigler M, Bach G. Gaucher disease type I and pregnancy. Am J Med Genet. 1989;32(4):475-7.
[96] Corcoy R, Aris A, de Leiva A. Fertility in a case of progeria. Am J Med Sci. 1989;297(6):383-4.
[97] Brown WT, Jenkins EC, Gross AC, Chan CB, Wisniewski K, Cohen IL, Miezejeski CM. Genetics and expression of the fragile X syndrome. Ups J Med Sci Suppl. 1987;44:137-54.
[98] Kolata G. Researchers seek melanoma gene. Science. 1986;232(4751):708-9.
[99] Minna JD, Battey JF, Brooks BJ, Cuttitta F, Gazdar AF, Johnson BE, Ihde DC, Lebacq-Verheyden AM, Mulshine J, Nau MM, et al. Molecular genetic analysis reveals chromosomal deletion, gene amplification, and autocrine growth factor production in the pathogenesis of human lung cancer. Cold Spring Harb Symp Quant Biol. 1986;51 Pt 2:843-53.
[100] Kok K, Osinga J, Carritt B, Davis MB, van der Hout AH, van der Veen AY, Landsvater RM, de Leij LF, Berendsen HH, Postmus PE, et al. Deletion of a DNA sequence at the chromosomal region 3p21 in all major types of lung cancer. Nature. 1987 Dec 10-16;330(6148):578-81.
[101] Retinoblastoma gene implicated in breast cancer development. Genet Eng News. 1988; 8(8):35.
[102] Larsen CJ. Genetic polymorphism and susceptibility to cancer. Nouv Rev Fr Hematol. 1988;30(1-2):39-43.
[103] Nebert D, Gonzales FJ. P450 genes: structure, evolution, regulation and relationship to cancer. 621 st Meet. Biochem. Soc.: Abstrs (London, 17-19 Dec., 1986). London, 1986: 33.
[104] Roberts L. New targets for human gene therapy. Science. 1988;241(4868):906–906.
[105] Single gene may predispose to heart disease. Genet Eng Biotechnol. Monit. 1986; 17:19-20.
[106] Rich SS, Green A, Morton NE, Barbosa J. A combined segregation and linkage analysis of insulin-dependent diabetes mellitus. Am J Hum Genet. 1987;40(3):237-49.
[107] Karlsson JL. Heterozygous inheritance of schizophrenia. Hereditas. 1987;107(1):59-64.
[108] Genetics of schizophrenia. Lancet. 1989;1(8629):79-80. Review.
[109] Barnes DM. Schizophrenia genetics a mixed bag. Science. 1988;242(4881):1009.
[110] Sugiura S, Mizokami M, Orito E et al. DR locus-inclusive HLA in persistent HBs antigen-positive patients. J Med Virol. 1987; 21(4):A85.
[111] Fine PE. Implications of genetics for the epidemiology and control of leprosy. Philos Trans R Soc Lond B Biol Sci. 1988;321(1207):365-76.
[112] Webster AD, Spickett GP, Thomson BJ, Farrant J. Viruses and antibody deficiency syndromes. Immunol Invest. 1988;17(2):93-105.
[113] Daminova NM. On genetic predisposition to viral hepatitis B. Actual Issues. anthropogenetics and toksikogenetiki. Tashkent, 1988:21-22.
[114] Seboun E, Robinson MA, Doolittle TH, Ciulla TA, Kindt TJ, Hauser SL. A susceptibility locus for multiple sclerosis is linked to the T cell receptor beta chain complex. Cell. 1989;57(7):1095-100.
[115] Schmidtke J. Moleculargenetische analyse menschicher erkrankungen. Mitt Dtsch Ges Klin Chem. 1989; 20(2):68-9.
[116] Brown WT. Premature aging syndromes. Clin Orient Int Symp Eur Soc Dermatol: res. (Oslo, 1986): Abstrs. Basel etc., 1987:152-65.
[117] Elenovskaya GF, Mitroschenko IV, Prisevok EK. Prevalence of allergic diathesis in children Minsk. Zdravookhraneniye Belorussii. 1985; 5:41-44.
[118] Surault P. Sur l'optimisme des hypotheses de mortalite dans Ies projections de 1'INSEE 1985. Trav et doc. 1988; 122:213-20.
[119] Fries JF, Green LW, Levine S. Health promotion and the compression of morbidity. Lancet. 1989;1(8636):481-3.
[120] Rose MR. The evolution of animal senescence. Can J Zool. 1984; 62(9):1661-7.
[121] Schott L. Krankheiten und seuchenzuge in mittelalterlichen bzw fruhneuzeitlichen Europa im ihrer demographischen bedeutung. Ethnogr archaol Z. 1988; 29(3):426-33.
[122] Population growth. Izvestia. 1990;42:5.
[123] Iwasaki H, Koresewa M. Fetal medicine. Its present status and future prospects. Asian Med J. 1989; 32(7):372-8.
[124] M?ller H, Mellemgaard A, Jensen OM. Measuring progress against cancer. J Cancer Res Clin Oncol. 1988;114(6):613-7.
[125] Scriver CR. Cases are not incidence and vice versa. Genet Epidemiol. 1988;5(6):481-7.
[126] Studenikin MIa. Current problems of infant mortality. Vestn Akad Med Nauk SSSR. 1988;(12):29-34.
[127] Isakov BI Without illusions. Smena. 1989; 12(2-3):16.
[128] Holden C. Why do women live longer than men? Science. 1987;238(4824):158-60.
[129] Gavrilov LA. Biology and demographic aspects of the study of life expectancy. Demographer study. M., 1988:105-121.
[130] Smith DW, Warner HR. Does genotypic sex have a direct effect on longevity? Exp Gerontol. 1989;24(4):277-88.
[131] Miklos GL, Matthaei KI, Reed KC. Occurrence of the (GATA)n sequences in vertebrate and invertebrate genomes. Chromosoma. 1989;98(3):194-200.
[132] Schneider-G?dicke A, Beer-Romero P, Brown LG, Nussbaum R, Page DC. ZFX has a gene structure similar to ZFY, the putative human sex determinant, and escapes X inactivation. Cell. 1989;57(7):1247-58.
[133] Jacques V. Duree de vie: Ies femmes creusent l'ecart. Popul et soc. 1988; 229:1-4.
[134] Schanz S, Steinbach P. Investigation of the "variable spreading" of X inactivation into a translocated autosome. Hum Genet. 1989;82(3):244-8.
[135] Scherer G, Schempp W, Baccichetti C, Lenzini E, Bricarelli FD, Carbone LD, Wolf U. Duplication of an Xp segment that includes the ZFX locus causes sex inversion in man. Hum Genet. 1989;81(3):291-4.
[136] Greer WL, Kwong PC, Peacocke M, Ip P, Rubin LA, Siminovitch KA. X-chromosome inactivation in the Wiskott-Aldrich syndrome: a marker for detection of the carrier state and identification of cell lineages expressing the gene defect. Genomics. 1989;4(1):60-7.
[137] Veyron P, el Habib R, Zabot MT, Maire I, Mathieu M, Touraine JL. Lysosomal enzyme deficiency: in vitro correlation of deficient cells using a conditioned medium or by co-culturing with non-deficient cells. Pathol Biol (Paris). 1989;37(1):35-8. French.
[138] Poulton J, Deadman ME, Gardiner RM. Duplications of mitochondrial DNA in mitochondrial myopathy. Lancet. 1989;1(8632):236-40.
[139] Sato W, Tanaka M, Ohno K, Yamamoto T, Takada G, Ozawa T. Multiple populations of deleted mitochondrial DNA detected by a novel gene amplification method. Biochem Biophys Res Commun. 1989;162(2):664-72.
[140] Tanaka-Yamamoto T, Tanaka M, Ohno K, Sato W, Horai S, Ozawa T. Specific amplification of deleted mitochondrial DNA from a myopathic patient and analysis of deleted region with S1 nuclease. Biochim Biophys Acta. 1989;1009(2):151-5.
[141] Young P. Cutting away DNA the mitochondrial way. Sci News. 1989; 136(6):85.
[142] King MP, Attardi G. Injection of mitochondria into human cells leads to a rapid replacement of the endogenous mitochondrial DNA. Cell. 1988;52(6):811-9.
[143] Davies KE, Ball SP, Dorkins HR, Forrest SM, Kenwrick SJ, King AW, Lavenir IJ, McGlade SA, Patterson MN, Smith TJ, et al. Molecular analysis of human X-linked diseases. Cold Spring Harb Symp Quant Biol. 1986;51 Pt 1:337-43.
[144] O'Connell P, Lathrop GM, Law M, Leppert M, Nakamura Y, Hoff M, Kumlin E, Thomas W, Elsner T, Ballard L, et al. A primary genetic linkage map for human chromosome 12. Genomics. 1987;1(1):93-102.
[145] Swain JL, Stewart TA, Leder P. Parental legacy determines methylation and expression of an autosomal transgene: a molecular mechanism for parental imprinting. Cell. 1987;50(5):719-27.
[146] Weissenbach J. Mapping the human Y chromosome. Philos Trans R Soc Lond B Biol Sci. 1988;322(1208):125-31.
[147] Page DC. Sex reversal: deletion mapping the male-determining function of the human Y chromosome. Cold Spring Harb Symp Quant Biol. 1986;51 Pt 1:229-35.
[148] Packer C. Molecular ecology. Trends EcolEvol. 1989;4(6):156–7.
[149] Komarov Yu M Shkolnikov VM. Medical and geographical analysis of mortality abroad. Itogi nauki i tekhniki. M. : VINITI, (Ser. med. geografii; N 16). 1989:1-200
[150] Schon D, Bertz J. Steigt die inzidenz von Krebskrankheiten?. BGA-Schriften. 1988; 4:24-31.
[151] Golemanov N. Mortality from cancer of men of working age (Trends and Prospects). Oncologiia. 1989; 26(1):3-9.
[152] Merz B. Mapping the human genome raises question: which road to take? JAMA. 1987;258(9):1131-2.
[153] Gudkov AV, A. T. Tihonenko retrovirus elements and the human genome. Itogi nauki i tekhniki.. VINITI, (Ser virusologiia; N 16) 1988:5-45.
[154] Langlois S, Deeb S, Brunzell JD, Kastelein JJ, Hayden MR. A major insertion accounts for a significant proportion of mutations underlying human lipoprotein lipase deficiency. Proc Natl Acad Sci U S A. 1989;86(3):948-52.
[155] Foutdevila A. The unstable genome: an evolutionary approach. Genet iber. 1987; 39(3-4):315-43.
[156] Sinkus A, Andryushkyavichyute I. Familial cases of Down syndrome. Status and prospects of genetics and breeding in Lithuania: Proc. Resp. conf. (26-27 October of 1989). Vilnius, 1989:26-27.
[157] Bahrenfeld LS, Nergadze SG, Andreeva LF et al. Radioresistant DNA synthesis in human genetic diseases: a new explanation. I Proc. radiobiol. Congress (Moscow, 21-27 August 1989) Proc. of reports. Pushchino, 1989; vol1:90-1.
[158] Vilenchik MM. Biological basis of aging and longevity. M:Znanie, 1987; 20 p.
[159] Richter C, Park JW, Ames BN. Normal oxidative damage to mitochondrial and nuclear DNA is extensive. Proc Natl Acad Sci U S A. 1988;85(17):6465-7.
[160] Jendryezko A, Drozdz M. Podstawowy pozion uszkodzen DNA komorek ludzkich. Pez lek. 1989; 46():470-3.
[161] Madden JJ, Falek SDA, Shafer DA et al. Influence of demographic factors on unscheduled DNA synthesis as measured in human peripheral leukocytes and fibroblasts. Individual susceptibility genotoxic agents hum popul: Proc workshop res. triangle park (May 10-12, 1982). New York; London, 1984. N 1:359-371.
[162] Tikhomirova MM. Heat shock proteins and mutagenesis. Vesti LGU. Ser. 3. 1989; 2:90-94.
[163] Schimke RT, Sherwood S, Johnston R et al. On the mechanism of induced gene amplification in mammalian cells. Accomplishments Oncol. 1987; 2(1):35-44.
[164] Miele M, Bonatti S, Menichini P, Ottaggio L, Abbondandolo A. The presence of amplified regions affects the stability of chromosomes in drug-resistant Chinese hamster cells. Mutat Res. 1989;219(3):171-8.
[165] Ross K, Haite Ns, Kelly K et al. DNA «fingerprint» changes in patients on combination chemotherapy. J Med Genet. 1989; 26(9):599-600.