Mathematical model of mutagenesis dynamics under the action of adenovirus DNA fragment
DOI:
https://doi.org/10.7124/bc.000427Abstract
Dynamics of mutagenesis in Chiniese hamster cells under the action of BAV3 DNA fragment containing transforming region is approximized by mathematical formulas on the basis of a model created by us It is shown that a set of parameters might be a foundation for classification as cell systems as their interactions with a mutagen. Variation of parameters and their optimization help us to identify genetic processes which are taking place in the cell population under the action of mutagenic factor and give a possibility to prognosticate results of cell system – mutagen interaction.References
Lukash LL, Buzhievskaya TI. Role of early viral genes in mutagenesis. Biotechnol Cur Prog. 1991; 1:119-31.
Mitropol'skii YuA. Some aspects of the application of differential equations in biology. Mat. Methods in Biology: Proceedings of the II Rep. Conf. Kiev: Naukova Dumka, 1983;3-8.
Grossman S, Turner J. Mathematics for the Biological Sciences. M.: Vyshch shkola, 1983; 383 p.
Babushkina IA. The mathematical model of the system "organism-tumor" for practicing effective chemotherapy regimens experimental tumors. Mat. modeling in immunology and medicine: Proc rep Intern meet. Kiev, 1989: 9-10.
Kostyuk PG et al. Biofizika. Kiev: Vyshcha shkola, 1988; 503 p.
Shnol SE Factors determining the direction and speed of biological evolution. Mat. modeling biol. processes. M.: Nauka, 1979; 22-3.
Auerbach C. Mutation research: problems, results and perspectives. 1976; London: Chapman & Hall. 504 p.
Hamming, Richard W. Numerical Methods for Scientists and Engineers. 1962 New York: McGraw-Hill.