2',5'-oligoadenylates effect on certain indexes of immune response
DOI:
https://doi.org/10.7124/bc.0003ADAbstract
Immunologic characteristics of different 2',5'-oligoadenylates were studied. It was shown that some core trimers of 2',5'-oligoadenylates have immunostimulative qualities while its epoxy-derivative has expressed immunosupressive character. These effects were obtained both in vitro and in vivo experiments.References
Pauwels R, De Clercq E, Balzarini F. Biological activity of new 2-5A analogues. Chemica Scripta. 1986; 26(2):141-5.
Torrence PF, Brozda D, Alster D, Charubala R, Pfleiderer W. Only one 3'-hydroxyl group of ppp5' A2'p5'A2'p5' A (2-5A) is required for activation of the 2-5A-dependent endonuclease. J Biol Chem. 1988;263(3):1131-9.
Sharma OK, Goswami BB, Cohrs RJ. Mechanism of growth inhibition of DNA containing viruses by interferon: role of 2-5A. The 2-5A system: Mol. and clinical aspects of the interferon-regulated pathway. New York: Alan. R. Liss, 1985: 317324.
Bayard B, Bisbal C, Silhol M, Cnockaert J, Huez G, Lebleu B. Increased stability and antiviral activity of 2'-O-phosphoglyceryl derivatives of (2'-5')oligo(adenylate). Eur J Biochem. 1984;142(2):291-8.
Paster EU, Ovod VV, Pozur VK, Vikhot' NE. Immunologiya. Prakticum. K. : Visha shk., 1989; 302 p.
Kozlov OV, Tkachuk ZIu, Korol' LIe. Hydrolysis and the products of 2',5'-oligoadenylate "core" cleavage. Ukr Biokhim Zh. 1993;65(2):35-42.
Zemskoe VM, Medunitsin NV Alekseev DP. Stimulation of cellular immunity and its low molecular weight RNA mononucleotides. Immunologiia. 1988; 1: 27-30.
Pat. T4378352. MKU A61K 19/20 USA (2'-5')Oligo-isoadenylate pharmaceutical compositions and method of use. A . Kimachi, M. Revel, S. Rappoport et al. Publ. 29.03.83.
