Search for antioxidants among derivatives of S-(quinaldine-4-yl)-L-cysteine
DOI:
https://doi.org/10.7124/bc.00066AAbstract
Toxic, antioxidant and ccrcbroprotectivc activities of several derivatives of S-(quinaldine-4-yl)-L-cysteine have been studied. It has been shown, that all investigated compounds normalize a Level of antioxidant enzymes, reduce the products of free radical oxidation and their activity exceed a known antioxidant dibunole. It has been established, that their activity substantially depends on a nature of the substituent in the position 6 of a quinoline cycle.References
Bilenko MV, Tel'pukhov VI, Churakova TD, Komarov PG. [Effect of ischemia and reperfusion of the rat brain on lipid peroxidation and the protective effect of antioxidants]. Biull Eksp Biol Med. 1988;105(4):394-7.
Bobyrev VN. [Free-radical oxidation in the pathogenesis of the diseases associated with aging]. Patol Fiziol Eksp Ter. 1989;(5):90-4.
Voskresenskiy ON. Influence of natural organic oxidants on pathological processes associated with aging. Jeneral problems of biology, M.: VINITI, 1986. Iss 6; 163-201.
Lipid peroxidation in normal and pathogenesis of various diseases: Sb. Nauch. Tr. Ed. MI Agadzhanova. Yerevan : Anastan, 1988; 220 p.
Stoklasov? A. Defence against the toxic action of oxygen. Sb Ved Pr Lek Fak Karlovy Univerzity Hradci Kralove. 1989;32(1):157-68.
Belenichev IF, Kovalenko SI, Brazhko OA, Karpenko OV. Research antioxidant action hinazolil-4- (4-quinolyl) -a f) - carboxylic acids in vitro and their derivatives under the conditions of initiating free radical processes and modeling of cerebral ischemia. Liki. 2001; (5-6):28-33.
Omelyanchik LO, Brazhko OA, Rylskiy OF. Search biologically active substances from S- (4-hinaldynil) - L-cysteine. Visn Zaporozh Derzh Univ. 1999; 1:190-4.
Kates M. Techniques of lipidology: isolation, analysis and identification of lipids. North-Holland Publishing Company, 1975; 269 p.
Dunaev VV, Belenichev IF, Kovalenko SI, Vashkin IN, Avramenko NA, Mazur IA, Knysh EG, Tishkin VS. [Antiradical and antioxidant activity of derivatives of 1,2,4-triazole and quinazoline in cerebral ischemia]. Ukr Biokhim Zh. 1996;68(1):100-4.
Kogan VS, Orlov ON, Prylypko LL. Problem analysis of endogenous lipid peroxidation products. M.: Meditsina, 1988; 287 p.
Andreeva LI, Kozhemiakin LA, Kishkun AA. [Modification of the method of determining lipid peroxidation in a test using thiobarbituric acid]. Lab Delo. 1988;(11):41-3.
Chevari S, Chaba I, Seke? I. [Role of superoxide dismutase in cellular oxidative processes and method of its determination in biological materials]. Lab Delo. 1985;(11):678-81.
Koroliuk MA, Ivanova LI, Ma?orova IG, Tokarev VE. [A method of determining catalase activity]. Lab Delo. 1988;(1):16-9.
Gavrilova AR, Khmara NF. [Determination of glutathione peroxidase activity in erythrocytes in saturated concentrations of the substrate]. Lab Delo. 1986;(12):721-4.
Belenichev IF. Method for determination of a-tocopherol in the biological material. Proc. rep. IV Congress of experts in laboratory clinical diagnosis of Belarus. Grodno, 1992; 72 p.
Yarovaya GA. The distribution of isoenzymes exchange chromatography method. Methods of separation and analysis in Biochemistry. M.: RIO UIOLUV, 1982;37-40.
Gatsura VV. Methods primary pharmacological studies of biologically active substances. M.: Meditsina , 1974; 143 p.
