N4-deriva tives of 6-azacytidine: synthesis and biological activity
DOI:
https://doi.org/10.7124/bc.00048CAbstract
Different methods of the synthesis of N4-derivatives of 6-azacytidine in conditions of simplified "sililic condensation" methods were investigated. Their antivirus activity with respect to the serotype 2 adenovirus in the culture of Hep-2 cells was studied. Primary specific activity of the compounds obtained was defined. Correlation between chemical structure of the new 6-azacytidine derivatives and its biological properties is discussed.References
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