The tetrahydrofuranylic derivatives of C6 substituted 3,5-dioxo- and 3,5-thioxo-1,2,4-triazines as a structural analogs of azapyrimidine nucleosides
DOI:
https://doi.org/10.7124/bc.000459Abstract
Influence of C6-aminoalkyl-, C6-mercaptoalkyl-substitutes of 3,5-dioxo- and 3,5-thioxo-derivatives 1,2,4-triazines on the process of tetrahydrofuranylation has been studied. This study was conducted in the conditions, similar to the one-step reaction of nucleic bases glycosylation. We discovered significant dependence of the regiospecifity of this reaction from electronic nature of substitutes in the 6-position.References
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