Template-free ribosomal synthesis of polypeptides from aminoacyl-tRNAs : polyphenylalanine synthesis from phenylalanyl-tRNALys
DOI:
https://doi.org/10.7124/bc.0001B2Abstract
Misacylated phenylalanyl-tRNALys, similar to lysyl-tRNALys, but not phenylalanyl-tRNAPhe, is able to serve as a substrate for ribosomal synthesis of polypeptides (poly-phenylalanine and polylysine, respectively) in the absence of a template polynucleotide (poly(A)). Thus, it is the structure of tRNA that determines the ability of the amino-acyl-tRNALys to participate in the peptide elongation on ribosomes without codon-anti-codon interactions.References
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