Antiviral activity of trimeric 2',5'-oligoadenylic acid and some of its analogues
DOI:
https://doi.org/10.7124/bc.0003FCAbstract
The authors have studied the antiviral effect of 2',5'-trioligoadenylate and of its derivatives using several model cell culture systems and viruses: L929 murinc fibroblast cells infected by vaccine virus, established testicular piglet cells inoculated by Aueszki disease virus (ADV) (strain BUK-628), and the same culture infected with Purdue-115 strain (reference strains of transmissible gastroenteritis virus (TGEV)). So, it is possible to suppose that both 2',5'-trioligoadenylate and its derivative are perspective antiviral preparations acting against DNA- and RNA-containing viruses.References
Itkes AV, Tunitskaia VL, Severin ES. Mechanisms of the regulation of the biological activity of the cell by 2',5-oligoadenylate. Biokhimiia. 1985;50(4):531-42.
Eppstein DA, Marsh YV, Schryver BB. Mechanism of antiviral activity of (XyloA2'p)2XyloA. Virology. 1983;131(2):341-54.
Fujihara M, Milligan JR, Kaji A. Effect of 2',5'-oligoadenylate on herpes simplex virus-infected cells and preventive action of 2',5'-oligoadenylate on the lethal effect of HSV-2. J Interferon Res. 1989;9(6):691-707.
Tominaga A, Saito S, Kohno S, Sakurai K, Hayakawa Y, Noyori R. Antiviral effects of 2',5'oligoadenylates (2-5As), and related compounds. Microbiol Immunol. 1990;34(9):737-47.
Müller WE, Weiler BE, Charubala R, Pfleiderer W, Leserman L, Sobol RW, Suhadolnik RJ, Schröder HC. Cordycepin analogues of 2',5'-oligoadenylate inhibit human immunodeficiency virus infection via inhibition of reverse transcriptase. Biochemistry. 1991;30(8):2027-33.
Montefiori DC, Sobol RW Jr, Li SW, Reichenbach NL, Suhadolnik RJ, Charubala R, Pfleiderer W, Modliszewski A, Robinson WE Jr, Mitchell WM. Phosphorothioate and cordycepin analogues of 2',5'-oligoadenylate: inhibition of human immunodeficiency virus type 1 reverse transcriptase and infection in vitro. Proc Natl Acad Sci U S A. 1989;86(18):7191-4.
Topchiy MK, Kornyushenko NP. Guide to practical training in virology. Kiev: Izd KSU, 1967: 230-237.
Tkachuk ZYu, Tkachuk LV, Kozlov AV, Kvasyuk EI, Zaitseva GV, Kalinichenko EN, Mikhailopulo IA, Matsuka GKh. Effect of (2'-5')oligoadenylates on the hydrolysis of the S1 Nuclease and DNA complex in vitro. Doklady Akad Nauk Ukr SSR. Ser B. 1988;(12):62–6.
