Oligonucleopeptides. III. Synthesis and studying oligonucleotidyl-(P→N)-peptides, containing arginine

Authors

  • S. M. Yarmoluk Institute of Molecular Biology and Genetics, NAS of Ukraine 150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680 Author
  • E. M. Ivanova Novosibirsk Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences 8, Akademika Lavrentieva Ave., Novosibirsk, Russian Federation, 630090 Author
  • I. V. Kondratjuk Institute of Molecular Biology and Genetics, NAS of Ukraine 150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680 Author
  • I. V. Alekseeva Institute of Molecular Biology and Genetics, NAS of Ukraine 150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680 Author
  • A. S. Shalamay Institute of Molecular Biology and Genetics, NAS of Ukraine 150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680 Author
  • V. F. Zarytova Novosibirsk Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences 8, Akademika Lavrentieva Ave., Novosibirsk, Russian Federation, 630090 Author

DOI:

https://doi.org/10.7124/bc.00033F

Abstract

Some arginine-containing oligonucleopeptides of phosphamide type were obtaining. We have studied effect of the peptide modification on the binding affinity and stability to trypsin of oligonucleopeptides

References

Uhlmann E, Peyman A. Antisense oligonucleotides: a new therapeutic principle. Chem Rev. 1990;90(4):543–84.

Leonetti J-P, Degols G, Milhaud P, Gagnor C, Lemaitre M, Lebleu B. Antiviral activity of antisense oligonucleotides linked to poly(L-lysine):targets on genomic RNA and/or mRNA of Vesicular Stomatitis Virus. Nucleosides Nucleotides Nucleic Acids. 1989;8(5):825–8.

Haralambidis J, Duncan L, Tregear GW. The solid phase synthesis of oligonucleotides containing a 3′-peptide moiety. Tetrahedron Lett. 1987;28(43):5199–202.

Yuodka BA. Covalent protein-nucleic structures and chemical modeling. Vilnius Mokslas, 1985. 176 p.

Kalashnikov VV, Samukov VV, Shubina TN, Yamshchikov VF. Application of the reverse-phase chromatography in oligonucleotide synthesis. Russian Journal of Bioorganic Chemistry. 1983, 9(5):666-672.

Yarmolyuk S. N., Pal'chikovskaya L. I., Fedoryak D. M. Chemical synthesis of nucleosides and nucleotides derivatives. Methods mol biol. Kiev: Naukova Dumka, 1986: 41-7.

Zarytova VF, Ivanova EM, Yarmolyuk SN, Alekseeva IV. Synthesis of arginine-containing oligonucleotide-(5'→N)-peptides. Biopolym Cell. 1988; 4(4):220-2.

Breitmaier E, Voelter W. Carbon-13NMR spectroscopy. VCR, 1987. 515 p.

Novoseler M. Distribution of large ligands on DNA macromolecules with different content of GC pairs.. Biofizika. 1962; 27, 6: 1000-4.

Permogorov VI, Fomenko TN, Semiletov IuA, Shvachkin IuP, Tiaglov BV. Interaction of tripeptides containing arginine and tyrosine (or phenylalanine) residues with synthetic polynucleotides and DNA of various origins. Mol Biol (Mosk). 1985;19(6):1514-8.

Published

1992-11-20

Issue

Section

Structure and Function of Biopolymers