The peculiarities of thrombin binding sites structure. Putative mechanisms of interaction with highmolecular and small substrates

Authors

  • L. V. Karabut Institute of Bioorganic Chemistry and Petrochemistry, NAS of Ukraine 1, Murmans'ka Str., Kyiv, Ukraine, 02094 Author
  • A. A. Sereyskaya Institute of Bioorganic Chemistry and Petrochemistry, NAS of Ukraine 1, Murmans'ka Str., Kyiv, Ukraine, 02094 Author

DOI:

https://doi.org/10.7124/bc.000336

Abstract

The peculiarities of active site structure and second binding site structure of thrombin is revealed. Alternative mechanisms of thrombin interaction with highmolecular or lowmolecular substrates are supposed. Also it is shown, putative function of the additional center of thrombin in productive enzyme-substrate complex formation.

References

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Published

1992-09-20

Issue

Section

Structure and Function of Biopolymers