The influence of the regulatory mutation in the rib1 locus on the riboflavin biosynthesis in Pichia guilliermondii
DOI:
https://doi.org/10.7124/bc.000306Abstract
The rib1-86 mutant of P. guilliermondii in which riboflavin auxotrophy is suppressed by mutation rib81, but not by rib80 was selected. Double ribl-86 rib81 mutant is characterized by low GTP-cyclohydrolase activity. The enzyme synthesis is faintly regulated by iron. It is supposed that ribl-86 mutation is localized in the promoter region of RIB1 gene which codes for GTP-cyclohydrolase.References
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