Exitable membrane ion channel as a self-organized non-equilibrium system. 1. Modelling of gate processes
DOI:
https://doi.org/10.7124/bc.000300Abstract
The interaction between ion flux and charged groups of channel results not only in the emergence of disprete levels of conductivity, but also enables us to describe gate processes, In the ion channel one link the activation is brought about the mobility of output barrier, and the inactivation – by input barrier in single channel ion profile. A comparison of this approach and Hodgkin–Haxley theory is suggested.References
Gaididei YB, Kharkyanen VN, Chinarov VA. Synergetic model of the voltage-gated ion channels in biological membranes. Kiev, 1988. 40 p. (Preprint. UkSSR. Inst theor. Physics; 123R).
Membranes. Ion channels. Ed. A. Chiznadzheva. M. Mir. 1981; 320 p.
Stühmer W, Conti F, Suzuki H, Wang XD, Noda M, Yahagi N, Kubo H, Numa S. Structural parts involved in activation and inactivation of the sodium channel. Nature. 1989;339(6226):597-603.
Eyring H, Urry DW. Thermodynamics and chemical kinetics. In: Theoretical and Mathematical Biology. Eds Waterman, T. and Morowitz, H. Blaisdell Publishing Co., 1965, 448 p.
Hodgkin AL, Huxley AF. A quantitative description of membrane current and its application to conduction and excitation in nerve. J Physiol. 1952;117(4):500-44.
Rubin AB. Biophysics. M. Vysshaya shkola,, 1987. vol. 2. 304 p.
Prigozhin I. From being to becoming. Moscow: Nauka, 1985. 327 p.
Gardiner C. W. Handbook of Stochastic Methods for Physics, Chemistry and the Natural Sciences. 2d ed. Springer-Verlag, 1985. 442 p.
