New polyfunctionalized 2-hydrazinoanthraquinone derivatives as potential antimicrobial agents
DOI:
https://doi.org/10.7124/bc.000A84Keywords:
anthraquinones, methylene active compounds, 4-thiazolidinones, antimicrobial activityAbstract
Aim. Synthesis and study of new polyfunctionalized 2-hydrazinoanthraquinone derivatives as potential antimicrobial agents. Methods. Organic synthesis, NMR and LC-MS spectroscopy, agar diffusion and broth microdilution methods. Results. A series of anthraquinonehydrazone derivatives are synthesized using the reaction of 2-(morpholinodiazenyl)anthracene-9,10-dione with methylene active compounds in the acetic acid medium. The screening of antimicrobial activity identified the compounds with significant effects against the tested microorganisms with MIC value <186.9 μM. Compounds 5 and 11 with MIC <93.5 μM are effective against yeast fungi whereas compound 5 with MIC <186.9 μM is effective against P.putida, which is multidrug resistant to antibiotics. Conclusions. The obtained hydrazino-anthraquinone derivatives constitute an interesting background for the design of new synthetic agents with antimicrobial activity.References
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