Research of antitumor ctivity of thioTEPA alkylated nucleic acid and nucleotides in vivo

Authors

  • T. P. Voloshchuk Institute of Molecular Biology and Genetics, NAS of Ukraine 150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680 Author
  • Yu. V. Patskovskii Institute of Molecular Biology and Genetics, NAS of Ukraine 150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680 Author
  • A. I. Potopalskii Institute of Molecular Biology and Genetics, NAS of Ukraine 150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680 Author
  • I. I. Vorobyeva Institute of Molecular Biology and Genetics, NAS of Ukraine 150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680 Author

DOI:

https://doi.org/10.7124/bc.0006BA

Abstract

The antitumor activity of the thioTEPA alkylated DNA preparations of various origin (cattle spleen, salmon sperm, chicken erythrocytes), yeast RNA and mononucleotides - ATP and GTP has been established in the experiments in vivo on mice with interweave Ehrlich carcinoma. The therapeutic doses (100–300 mg/kg of the weight) of these preparations insured the tumor growth inhibition by 90–100 % at the toxic dose LD50 between 1.5 and 2 g/kg. The DNA preparations, modified by monofunctional alkylating agents (ethylenimine and monoaziridinediethylphosphate), have no noticeable antitumor effect.

References

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Published

2004-07-20

Issue

Vol. 20 No. 4 (2004)

Section

Molecular Biomedicine