Among Escherichia coli Genetic Stock Center strains many are resistant to cytotoxic antimetabolites

Authors

  • E. I. Cherepenko Institute of Molecular Biology and Genetics, NAS of Ukraine 150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680 Author
  • O. I. Karpenko Institute of Molecular Biology and Genetics, NAS of Ukraine 150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680 Author

DOI:

https://doi.org/10.7124/bc.000606

Abstract

Mutants resistant to cytotoxic antimetabolites arise in E. coli with a frequency about 10–4. Because most in this collection strains contacted a mutagen we checked how many strains could tolerate two inhibitors used: glyphosate and 6-aza-uracil. Among 28 strains studied 12 could tolerate these inhibitors.

References

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Cherepenko EI, Karpenko OI, Maluta SS. Genetic mechanisms of Escherichia coli cell resistance to amino acid antimetabolites. 1. Search for genes other than glyphosate target gene. Biopolym Cell. 1994; 10(3-4):79-83.

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Godoy VG, Gizatullin FS, Fox MS. Some features of the mutability of bacteria during nonlethal selection. Genetics. 2000;154(1):49-59.

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Published

2002-05-20

Issue

Vol. 18 No. 3 (2002)

Section

Short Communications