The combinatorial approach to the synthesis of new 6-aza analogs of the uracil and thymine
DOI:
https://doi.org/10.7124/bc.000588Abstract
A new one stage method of the synthesis of 3-hydrazino-2H-l,2,4-tliriazin-5-one and 3-hydrazino-6-methyl-2H-l,2,4-thriazin-5-one has been designed in order to create the combinatorial libraries. The series of new 2-(N'-benzylydene-hydrazino)-6-asawacils and 2-(N'-benzylydene-hydrazino)-6-azathymins have been obtained.References
de Kloet SR. Effects of 5-fluorouracil and 6-azauracil on the synthesis of ribonucleic acid and protein in Saccharomyces carlsbergensis. Biochem J. 1968;106(1):167-78.
Itogi nauki i tekhniki. Ser. Bioorganicheskaya khimiya. Moscow, 1984. vol 1. 66 p.
Pat. France N 9308259. Fabre Medicament. Nouveaux derives de la 3.5-dioxo-(2H,4H)-l,2,4-triazine, leur preparation et leur therapeutique humanie / Clopaert F., Briley M., Imbert T
Pesticide Manual. Ed. AV Pavlova. Kiev: Urozhai, 1986. 208 p.
Jaeger G. Chemistry of pesticides. Ed. K. H. Buechel. New York: John Wiley and Sons, 1983: 338.
Commercial opportunities in combinatorial chemistry. Bioinformation Associates. Boston: MA, 1995: 14.
Hogan JC Jr. Combinatorial chemistry in drug discovery. Nat Biotechnol. 1997;15(4):328-30.
Libermann D, Jacquier R. Sur quelques nouveaux derives de la triazine asymmetrique. Bull. Soc. Chim. Franse. 1961; 38: 383-90.
Khamaev VH, Danilov VA, Khannanov RYA, Mazitova AK. Derivatives of 1,2,4-triazin-5-one. Zh Org Khim. 1990; 30(5):777-81.
ORGANIKUM. Organisch-chemisches Grundpraktikum. Eds Becker H, VEB Deutscher Verlag der Wissenschaften Berlin 1990
Mazor L. Methods of organic Analysis Akademiai Kiado Budapest 1983.
The Systematic Identification of Organic Compounds. Eds: Shriner RL, Fuson RC, Curtin DY, Morrill TC 1980 John Wiley & Sons, Inc.
Dornow A, Abele W, Menzel H. Synthesen stickstoffhaltiger Heterocyclen, XXVIII. ?ber 1.2.4-Triazine, II. Darstellung einiger neuers-Triazolo[4.3-b]-as-triazine. Chem Ber. 1964;97(8):2179–84.
Labouta IA, Eshba NH, Salama HM. Potential antineoplastics: synthesis and anticancer evaluation of some substituted 1,2,4-triazines. Farm Sci Ed. 1988; 16(2):29-34.
Sykes P. Guidebook to Mechanism in Organic Chemistry Prentice Hall; 1986. 432 p.
Hadacek Matulova D. Substituted asymmetric triazines. Spisy Prirodovedecke Fak. Univ. Brne. 1965. N 462: 161-174.
Khannanov RYA, Khamaev VH. Status and prospects of the range of chemicals for the most important sectors of the economy and research. Proc. rep. 3rd All-Union. soveshch. by chem. reagents (Ashgabat, 19-23 Sep. 1989). Vol 1: 178.
Prystas M, Sorm F. Nucleic acids components and their analogues. XL. Synthesis of 5-methyl-2'-deoxy-6-azacytidine. Collect Czech Chem Comm. 1963. 28(10): 2598-604.
