Search for HIV and herpes Inhibitors among the derivatives of polyhedranee and pyridinecarboxylic acid
DOI:
https://doi.org/10.7124/bc.00051AAbstract
It was found that an adamantane derivative (5) inhibits HIV replication as azidothymidin but has immuitostimu/ative properties. The derivatives of isonicotinic acid (2) anil norbornane (4) manifest both antiherpes and immunostimu/ative activity.References
Usova E, Blinov V, Goltzov V. et aL Inhibitory of HIV reproduction by membranotropic compound: IX Int. Conf. on AIDS: Abetr. Brusseel, 1993:29.
A. S. SSSR 563796. 1976.
A. S. SSSR 686296. 1978.
A. S. SSSR 582663. 1978.
Clercq E. De. Chemotherapy of acute HIV-infection. X Int. Conf. on AIDS: Abstr. Nizza, 1994:3.
Kondo T, Siba M. Polymers pharmacological destination, M.: Medicine, 1981:144—189.
Lotze M. AIDS. Etiology. Diagnosis, Treatment and Prevention. Phyladelphia: Upincott corp., 1985:235.
ABC of AIDS. Ed. M. Adler, M Mir, 1991. 69.
Methodical materials for experimental (pharmacological) and clinical trials of immunomodulatory action of pharmacological agents: Izdnie offitsialnoe, M., 1984:9-10.
E. Siegel hemagglutination reaction. Immunological Methods, Wiley, 1979:108-112.
Giulling EV, Sambur MB. In vivo reproduction and evaluation of delayed type hypersensitivity. Fiziol Zh. 1981;27(2):237-40.
Automated processing methods of experimental and clinical data using calculators: Guidelines. Kyiv, 1985: 25.
Chaudhuri TK, Chakravarty AK. Activation of murine thymocytes in vivo. Part II: Study of blastogenesis, the synthesis of macromolecules and the cytotoxic response after stimulation with phytohemagglutinin. Lymphology. 1986;19(3):117-24.
