Biopolym. Cell. 1995; 11(5):56-60.
http://dx.doi.org/10.7124/bc.0003FC
Antiviral activity of trimeric 2',5'-oligoadenylic acid and some of its analogues
1Tkachuk Z. Yu., 1Semernikova L. I., 1Tkachuk V. V., 2Reshotko L. M., 2Mikhailopulo I. A., 1Matsuka G. Kh.
  1. Institute of Molecular Biology and Genetics, NAS of Ukraine
    150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680
  2. Institute of Bioorganic Chemistry, NAS of Belarus
    5/2, Kuprevich Str., Minsk, Republic of Belarus, 220141

Abstract

The authors have studied the antiviral effect of 2',5'-trioligoadenylate and of its derivatives using several model cell culture systems and viruses: L929 murinc fibroblast cells infected by vaccine virus, established testicular piglet cells inoculated by Aueszki disease virus (ADV) (strain BUK-628), and the same culture infected with Purdue-115 strain (reference strains of transmissible gastroenteritis virus (TGEV)). So, it is possible to suppose that both 2',5'-trioligoadenylate and its derivative are perspective antiviral preparations acting against DNA- and RNA-containing viruses.
Full text: (PDF, in Ukrainian)

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