Biopolym. Cell. 1988; 4(4):220-222.
Short Communications
Synthesis of arginine-containing oligonucleotide-(5'→N)-peptides
1Zarytova V. F., 1Ivanova E. M., 2Yarmolyuk S. N., 2Alekseeva I. V.
  1. Institute of Bioorganic Chemistry, Siberian Branch of the Academy of Sciences of the USSR
    Novosibirsk, USSR
  2. Institute of Molecular Biology and Genetics, Academy of Sciences of the Ukrainian SSR
    Kiev, USSR

Abstract

A new method for synthesis of oligonucleotide-peptides of phosphoamide type with the use of a mixture of triphenylphosphine, dipyridyldisulphide and N-methylimidazole is suggested. This approach was applied for synthesizing and isolating d(CCCC)-5'-P-Pro-Arg-Val-OMe.

References

[1] Juodka BA. Covalent nucleic acid-protein structures and their chemical modeling. Vilnius, Mokslas, 1985; 176 p.
[2] Juodka BA. Synthesis, properties and application of nucleotide-peptides of the phosphoester and phosphoamide types. Russian Journal of Bioorganic Chemistry. 1984; 10(2):149-69.
[3] Smirnov VD, Ivanovskaya MG, Il'yina EV et al. Synthesis of the phenylalanine amide of a pentadeoxynucleotide. Dokl Akad Nauk SSSR. 1972; 206(5):1133-6.
[4] Andreev SM, Galkin OM, Rogozhin SV, Samoilova NA. Synthesis of tuftsin and NE-lysine-substituted peptides as model compounds for studying the enzymatic hydrolysis of modified proteins. Russian Journal of Bioorganic Chemistry. 1986;12(6):725-32.
[5] Grinshteine IV, Myshliakova NV, Vegner RE, Vosekalna IA, Gailite EA. Synthesis and study of cyclic and linear analogs of neurotensin. Bioorg Khim. 1985;11(12):1589-97.
[6] Godovikova TS, Zarytova VF, Khalimskaya LM. Reactive phosphamidates of mono- and dinucleotides. Russian Journal of Bioorganic Chemistry. 1986; 12 (4):475-81.
[7] Lebedev AV, Rezvukhin AI. Tendencies of the phosphorus nuclei chemical shift changes in 31P NMR spectra of nucleotide derivatives. Russian Journal of Bioorganic Chemistry. 1983; 9(2):149-85.
[8] Baram GI, Grachev SA. Use of lithium perchlorate for isolation and analysis of oligo- and polynucleotides. Russian Journal of Bioorganic Chemistry. 1985; 11(10):1420-2.
[9] Nevinsky GA, Ankilova VN, Lavrik OI, Mkrtchyan ZS, Nersesova LS, Akopyan JI. Functional non-identity of creatine kinase subunits of rabbit skeletal muscle. FEBS Lett. 1982;149(1):36-40.
[10] Gottikh MB, Ivanovskaya MG, Shabarova ZA. Synthesis of phosphoramidates of mono- and oligonucleotides in aqueous media. Russian Journal of Bioorganic Chemistry. 1983; 9(8):1063-7.