Biopolym. Cell. 2021; 37(1):73-82.
Биоинформатика
Изменения в плацентарном транскриптоме человека в течение физиологического течения беременности
1Лихенко О. К., 1Фролова А. А., 1Оболенська М. Ю.
  1. Институт молекулярной биологии и генетики НАН Украины
    ул. Академика Заболотного, 150, Киев, Украина, 03143

Abstract

Цель. Определить как меняется экспрессия генов в плаценте человека в течение физиологической беременности. Методы. Интегративный анализ имеющихся в открытом доступе данных. Результаты. Показано, что в интервале между первым и вторым триместром основные изменения касаются иммунных процессов, морфогенеза и межклеточного общения через поверхностные рецепторы клеточной мембраны. В интервале между вторым и третьим триместром основные изменения касаются регуляции ответа на внешний стимул, метаболических процессов, морфогенеза отдельных тканей, регуляции сигнальных путей через трансмембранные серин/треонин протеинкиназные рецепторы. Выводы. Изменения в экспрессии генов плаценты на протяжении физиологического течения беременности будут служить надежным контролем для сравнения с изменениями при патологическом течении беременности
Keywords: плацента человека, транскриптом, интегративный анализ

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