Biopolym. Cell. 2020; 36(3):197-209.
Обзоры
Полифункциональные свойства белков козьего молозива и их использование
1Солошенко К. И., 1Лыч И. В., 1, 2Волошина И. Н., 3Шкотова Л. В.
  1. Национальный университет пищевых технологий
    ул. Владимирская, 68, Киев, Украина, 01601
  2. Киевский национальный университет технологий и дизайна
    ул. Немировича-Данченко, 2, Киев, Украина, 01011
  3. Институт молекулярной биологии и генетики НАН Украины
    ул. Академика Заболотного, 150, Киев, Украина, 03143

Abstract

В обзоре описан состав козьего молозива, антимикробные, иммуномодулирующие и антиоксидантные свойства биологически активных белков молозива коз, а также рассмотрены перспективы их применения в медицине. Благодаря наличию комплекса биологически активных белков, таких как лактоферрин, лизоцим, лактопероксидаза, иммуноглобулины и т.д., козье молозиво способствует повышению устойчивости организма к инфекционным заболеваниям, укреплению иммунной системы, обладает антибактериальной активностью в отношении широкого спектра микроорганизмов, обладает антиоксидантным действием, тем самым предотвращая или задерживая хронические заболевания, связанные с окислительным стрессом. Кроме этого, биоактивные белки молозива коз демонстрируют противоопухолевую активность, антиатерогенные свойства, способность снижать артериальное давление и проявляют эффективность в лечении ревматоидного артрита.
Keywords: козье молозиво, белковый комплекс, антимикробная активность, иммуномодулирующие свойства, антиоксидантный эффект, терапевтическое применение

References

[1] Zazharska NM, Samoylenko YuV. Chemical and immunological parameters of goat colostrum and milk depending on lactation period. Visnyk Dnipropetrovskoho derzhavnoho ahrarno-ekonomichnoho universytetu. 2016; 2(40):70-5.
[2] Biadała A, Konieczny P. Goat's milk-derived bioactive components - a review. Mljekarstvo. 2018; 68(4):239-53.
[3] Abbas HM, Hassan FAM, Abd El-Gawad MAM, Enab AK. Physicochemical characteristics of goat's milk. Life Sci J. 2014; 11(1):307-17.
[4] Busol LV, Tsyvirko IL, Pavlichenko OV, Heyda IM. Features and requirements for quality and safety of goat milk. Problemy zooinzheneriyi ta veterynarnoyi medytsyny. 2015; 30(2):274-76.
[5] Rashid AA, Yousaf M, Salaryia AM, Ali S. Studies on the nutritional composition of goat (Beetal) colostrum and its mature milk. Pak J Biochem Mol Biol. 2012; 45(3):113-16.
[6] Sánchez-Macías D, Moreno-Indias I, Castro N, Morales-delaNuez A, Argüello A. From goat colostrum to milk: Physical, chemical, and immune evolution from partum to 90 days postpartum. J Dairy Sci. 2014; 97(1):10-16.
[7] Rachman AB, Maheswari RRA, Bachroem MS. Composition and isolation of lactoferrin from colostrum and milk of various goat breeds. Procedia Food Sci. 2015; 3:200-10.
[8] Azhar MA, Salim N. Isolation and molecular characterization of local goat milk casein for nutraceutical value. MATEC Web Conf. 2017; 97:01084.
[9] Jung TH, Hwang HJ, Yun SS, Lee WG, Kim JW, Ahn JY, Jeon WM, Han KS. Hypoallergenic and physicochemical properties of the A2 β-casein fraction of goat milk. Korean J Food Sci Anim Resour. 2017; 37(6):940-47.
[10] Sanmartín B, Díaz O, Rodríguez-Turienzo L, Cobos A. Composition of caprine whey protein concentrates pro-duced by membrane technology after clarification of cheese whey. Small Rum Res. 2012; 105(1-3):186-92.
[11] Bolhova NV. Analysis of milk mixtures based on goat milk. Pratsi TDATU. 2018; 18(1):37-42.
[12] Loch JI, Bonarek P, Polit A, Świątek S, Czub M, Ludwikowska M, Lewiński K. Conformational variability of goat β-lactoglobulin: Crystallographic and thermodynamic studies. Int J Biol Macromol. 2015; 72:1283-91.
[13] Yang Y, Bu D, Zhao X, Sun P, Wang J, Zhou L. Proteomic analysis of cow, yak, buffalo, goat and camel milk whey proteins: quantitative differential expression patterns. J Proteome Res. 2013; 12(4):1660-67.
[14] Yuan YG, An L, Yu B, Song S, Zhou F, Zhang L, Gu Y, Yu M, Cheng Y. Expression of recombinant human alpha-lactalbumin in the milk of transgenic goats using a hybrid pomoter/enhancer. J Anal Methods Chem. 2014; 2014:281031.
[15] Vijayan S, Radhakrishnan U, Eldho L, Jayavardhanan KK. Isolation and purification of lactoferrin from colo-strum of malabari goats. J Exp Biol Agricult Sci. 2017; 5(4):550-55.
[16] Medeiros GKVV, Queiroga RCRE, Costa WKA, Gadelha CAA, Lacerda RR, Lacerda JTJG, Pinto LS, Braganhol E, Teixeira FC, Barbosa PPS, Campos MIF, Gonçalves GF, Pessôa HLF, Gadelha TS. Proteomic of goat milk whey and its bacteriostatic and antitumour potential. ‎Int J Biol Macromol. 2018; 113:116-23.
[17] Le Parc A, Dallas DC, Duaut S, Leonil J, Martin P, Barile D. Characterization of goat milk lactoferrin N-glycans and comparison with the N-glycomes of human and bovine milk. Electrophoresis. 2014; 35(11):1560-70.
[18] Lu J, Liu L, Pang X, Zhang S, Jia Z, Ma C, Zhao L, Lv J. Comparative proteomics of milk fat globule membrane in goat colostrum and mature milk. Food Chem. 2016; 209:10-16.
[19] Sharma G, Rout PK, Kaushik R, Singh G. Identification of bioactive peptides in goat milk and their health application. J Adv Dairy Res. 2017; 5(4):1000191.
[20] Larsson NG, Wang J, Wilhelmsson H, Oldfors A, Rustin P, Lewandoski M, Barsh GS, Clayton DA. Mitochondrial transcription factor A is necessary for mtDNA maintenance and embryogenesis in mice. Nat Genet. 1998; 18:231-36.
[21] Pham CT, Ley TJ. Dipeptidyl peptidase I is required for the processing and activation of granzymes A and B in vivo. Proc Natl Acad Sci USA. 1999; 96(15):8627-32.
[22] Lima MJR, Teixeira-Lemos E, Oliveira J, Teixeira-Lemos LP, Monteiro AM, Costa JM. Nutritional and health profile of goat products: focus on health benefits of goat milk. Goat Sci. 2018; 10:189-232.
[23] Castro N, Gómez-González LA, Earley B, Argüello A. Use of clinic refractometer at farm as a tool to estimate the IgG content in goat colostrum. J Appl Anim Res. 2018; 46(1):1505-08.
[24] Osman A, Goda HA, Abdel-Hamid M, Badran SM, Otte J. Antibacterial peptides generated by Alcalase hydrolysis of goat whey. LWT-Food Sci Technol. 2016; 65:480-86.
[25] Almaas H, Eriksen E, Sekse C, Comi I, Flengsrud R, Holm H, Vegarud GE. Antibacterial peptides derived from caprine whey proteins, by digestion with human gastrointestinal juice. Br J Nutr. 2011; 106(6):896-905.
[26] Esmaeilpour M, Ehsani MR, Aminlari M, Shekarforoush Sh, Hoseini E. Antimicrobial peptides derived from goat's milk whey proteins obtained by enzymatic hydrolysis. J Food Biosci Technol. 2017; 7(1):65-72.
[27] Kusumaningtyas E, Widiastuti R, Kusumaningrum HD, Suhartono MT. Antimicrobial and antioxidative activities of peptides from goat milk hydrolyzed with various protease. JITV. 2015; 20(3):175-83.
[28] Yadav AK, Singh J, Yadav SK. Composition, nutritional and therapeutic values of goat milk: A review. Asian J Dairy Food Res. 2016; 35(2):96-102.
[29] Lestari P. Antibacterial activity of hydrolysate protein from Etawa goat milk hydrolysed by crude extract brome-lain IOP Conf Ser Mater Sci Eng. 2019; 509(1):012111.
[30] Maga EA, Weimer BC, Murray JD. Dissecting the role of milk components on gut microbiota composition. Gut microbes. 2013; 4(2):136-139.
[31] Kumar H, Yadav D, Kumar N, Seth R, Goyal AK. Nutritional and nutraceutical properties of goat milk-a re-view. Indian J Dairy Sci. 2016; 69:513-518.
[32] Avaiyarasi ND, Ravindran AD, Venkatesh P, Arul V. In vitro selection, characterization and cytotoxic effect of bacteriocin of Lactobacillus sakei GM3 isolated from goat milk. Food Control. 2016; 69:124-133.
[33] Anas M, Zinedine BA, Rizk HA, Eddine HJ, Mebrouk K. Screening of autochthonous Lactobacillus species from Algerian raw goats' milk for the production of bacteriocin-like compounds against Staphylococcus aureus. Afr J Biotechnol. 2012; 11(20):4595-4607.
[34] Araújo DFS, Guerra GCB., Pintado MME, Sousa YRF, Algieri F, Rodriguez-Nogales A, Rodriguez-Cabezas ME. Intestinal anti-inflammatory effects of goat whey on DNBS-induced colitis in mice. PLoS One. 2017; 12(9):e0185382.
[35] de Sousa YRF, da Silva Vasconcelos MA, Costa RG, de Azevedo Filho CA, de Paiva EP, do Egypto RDCR. Sialic acid content of goat milk during lactation. Livestock Sci. 2015; 177:175-80.
[36] Kalyan S, Meena S, Kapila S, Sowmya K, Kumar R. Evaluation of goat milk fat and goat milk casein fraction for anti-hypercholesterolaemic and antioxidative properties in hypercholesterolaemic rats. Int Dairy J. 2018; 84:23-27.
[37] Ahmed AS, El-Bassiony T, Elmalt LM, Ibrahim HR. Identification of potent antioxidant bioactive peptides from goat milk proteins. Food Res Int. 2015; 74:80-88.
[38] Bezerra VS, Campos JF, Silva RAD, Porto TS, Lima Filho JLD, Porto ALF. Biotechnological richness of the northeastern semi-arid region: antioxidant activity of casein hydrolysates from Moxotó goat milk (Capra hircus Linnaeus, 1758) obtained by papain action. Food Sci Technol. 2013; 33(3):513-20.
[39] Mal G, Singh B, Mane BG, Sharma V, Sharma R, Bhar R, Dhar JB. Milk composition, antioxidant activities and protein profile of Gaddi goat milk. J Food Biochem. 2018; 42(6):e12660.
[40] Li Z, Jiang A, Yue T, Wang J, Wang Y, Su J. Purification and identification of five novel antioxidant peptides from goat milk casein hydrolysates. J Dairy Sci. 2013; 96(7):4242-51.
[41] De Gobba C, Espejo-Carpio FJ, Skibsted LH, Otte J. Antioxidant peptides from goat milk protein fractions hy-drolysed by two commercial proteases. Int Dairy J. 2014; 39(1):28-40.
[42] Abbas ZH, Doosh KS, Yaseen NY. Study the effect of purified goat milk lactoferrin on HeLa Cancer Cell line Growth in vitro. Iraqi J Cancer Med Genet. 2015; 8(2):170-75.
[43] Nandhini B, Palaniswamy M. Anticancer effect of goat milk fermented by Lactobacillus plantarum and Lactobacillus paracasei. Int J Pharm Pharm Sci. 2013; 5(3):898-901.
[44] Ibrahim HR, Ahmed AS, Miyata T. Novel angiotensin-converting enzyme inhibitory peptides from caseins and whey proteins of goat milk. J Adv Res. 2017; 8(1):63-71.
[45] Tagliazucchi D, Shamsia S, Helal A, Conte A. Angiotensin-converting enzyme inhibitory peptides from goats' milk released by in vitro gastro-intestinal digestion. Int Dairy J. 2017; 71:6-16.
[46] Espejo-Carpio FJ, De Gobba C, Guadix A, Guadix EM, Otte J. Angiotensin I-converting enzyme inhibitory activity of enzymatic hydrolysates of goat milk protein fractions. Int Dairy J. 2013; 32(2):175-83.
[47] Miglani S, Patyar RR, Patyar S, Reshi MR. Effect of goat milk on hepatotoxicity induced by antitubercular drugs in rats. J Food Drug Anal. 2016; 24(4):716-21.
[48] Poutzalis S, Anastasiadou A, Nasopoulou C, Megalemou K, Sioriki E, Zabetakis I. Evaluation of the in vitro anti-atherogenic activities of goat milk and goat dairy products. Dairy Sci Technol. 2016; 96(3):317-27.
[49] Fatchiyah F, Setiawan B, Suharjono S, Noor Z. The anti-osteoporosis effects of CSN1S2 protein of goat milk and yoghurt on a complete Freund's adjuvant-induced rheumatoid arthritis model in rats. Biomark Genom Med. 2015; 7(4):139-46.
[50] Rohmah RN, Widjajanto E, Fatchiyah F. Protective effect of CSN1S2 protein of goat milk on ileum microstructure and inflammation in rat-CFA-induced rheumatoid arthritis. Asian Pac J. Trop Dis. 2015; 5(7):564-68.