Biopolym. Cell. 2014; 30(5):349-357.
Обзоры
Молекулярные механизмы многосторонней биологической активности интерлейкина-7
1Сливка А. В., 2Окунев О. В.
  1. Учебно-научный центр «Институт биологии»
    Киевского национального университета имени Тараса Шевченко
    ул. Владимирская, 64/13, Киев, Украина, 01601
  2. Институт молекулярной биологии и генетики НАН Украины
    ул. Академика Заболотного, 150, Киев, Украина, 03680

Abstract

В результате иммунологических исследований последних 25 лет показано, что интерлейкин-7 (ИЛ-7) является одним из важнейших регуляторных цитокинов иммунной системы. Он оказывает значительное влияние на развитие, пролиферацию и активацию иммунных клеток, онднако не принадлежит к классическим цитокинам-активаторам, как, например, ИЛ-2, поскольку много типов клеток нуждаются в его присутствии почти на всех стадиях своего развития, а спектр его активностей впечатляет. Цель этого обзора состояла в обощении многочисленных данных по структуре ИЛ-7, его биологической активности и особенностям функционирования in vitro и in vivo. Основной акцент сделан на путях сигнальной трансдукции ИЛ-7, определяющих судьбу Т- и В-клеток, а также некоторых других клеток, важных для поддержания гомеостаза организма. Анализ литературы этой сферы, по нашему мнению, не только выявил ряд вопросов, на которые до сих пор нет ответов, но и очертил направления для будущих исследований.
Keywords: цитокин, иммунная система, сигнальная трансдукция, регуляция

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