Biopolym. Cell. 2014; 30(3):184-189.
Миниобзоры
Механизмы активации мономерных рецепторов цитокинов: лиганд-независимая и лиганд-индуцированная димеризация
1, 2Гришкова В. С., 3Албу Р. И., 1, 2Константинеску С. Н.
  1. Людвиговский институт исследования рака, Брюссельский филиал
    пр-т Гиппократа 74, Bte B1.74.03, Брюссель, BRU, Бельгия, 1200
  2. Католический университет Левена, де Дюв Институт
    пр-т E. Мунье 53, Брюссель, B1200, Бельгия
  3. Клиника университета Санкт-Люк
    пр.-тГиппократ 10 B1200 Брюссель, Бельгия

Abstract

Несмотря на интенсивные исследования, механизмы активации цитокиновых рецепторов до сих пор не полностью изучены. Исторически было предложено две модели: ранние работы предполагали механизм лиганд-индуцированной димеризации рецепторов, что приводит к активации более поздних сигнальных путей, в то время как при отсутствии лигандов рецепторы находятся в мономерном неактивном состоянии; последующие исследования выявили доказательства существования многих рецепторов в форме неактивированных сформированных димеров, которые при связывании лиганда претерпевают конформационные изменения и/или мономеры которых начинают ротационно перемещаться относительно друг друга. Данный обзор сфокусирован на проблеме димеризации отдельных гомодимерних рецепторов цитокинов, вовлеченнх в регуляцию кроветворения.
Keywords: рецепторы цитокинов, димеризация, гематопоез

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