Biopolym. Cell. 2009; 25(5):372-383.
Обзоры
Молекулярный шаперон Hsp90: структура, функции и участие в кардиоваскулярной патологии
1Крупская И. В.
  1. Институт молекулярной биологии и генетики НАН Украины
    ул. Академика Заболотного, 150, Киев, Украина, 03680

Abstract

Обзор посвящен анализу структурных и функциональных свойств молекулярного шаперона Hsp90. Hsp90 является представителем широко распространенного семейства белков теплового шока. Он обнаружен в бактериях и в эукариотах, но отсутствует в архебактериях, служит также одним из ключевых регуляторов многочисленных сигнальних путей, определяющих рост и развитие клеток, апоптоз, индукцию аутоиммунных реакций и прогрессию сердечной недостаточности. Полная функциональная активность этого белка проявляется в комплексе с другими молекулярними шаперонами и кошаперонами. Молекулярные взаимодействия между шаперонами, различными сигнальными белками и белками-партнерами критичны для нормального функционирования сигнальных путей, а нарушение их вызывает изменения в физиологии клетки вплоть до ее гибели.
Keywords: Hsp90, домен, кристаллическая структура, сигнальный путь, апоптоз

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