Biopolym. Cell. 2002; 18(3):253-254.
Short Communications
Among Escherichia coli Genetic Stock Center strains many are resistant to cytotoxic antimetabolites
1Cherepenko E. I., 1Karpenko O. I.
  1. Institute of Molecular Biology and Genetics, NAS of Ukraine
    150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680

Abstract

Mutants resistant to cytotoxic antimetabolites arise in E. coli with a frequency about 10–4. Because most in this collection strains contacted a mutagen we checked how many strains could tolerate two inhibitors used: glyphosate and 6-aza-uracil. Among 28 strains studied 12 could tolerate these inhibitors.

References

[1] Kishore GM, Shah DM. Amino acid biosynthesis inhibitors as herbicides. Annu Rev Biochem. 1988;57:627-63.
[2] Comai L, Sen LC, Stalker DM. An Altered aroA Gene Product Confers Resistance to the Herbicide Glyphosate. Science. 1983;221(4608):370-1.
[3] Cherepenko EI, Karpenko OI, Maluta SS. Genetic mechanisms of Escherichia coli cell resistance to amino acid antimetabolites. 1. Search for genes other than glyphosate target gene. Biopolym Cell. 1994; 10(3-4):79-83.
[4] Cairns J, Foster PL. Adaptive reversion of a frameshift mutation in Escherichia coli. Genetics. 1991;128(4):695-701.
[5] Godoy VG, Gizatullin FS, Fox MS. Some features of the mutability of bacteria during nonlethal selection. Genetics. 2000;154(1):49-59.