Biopolym. Cell. 2001; 17(5):428-433.
Molecular Biomedicine
Heparin and rat brain heparin-binding proteins take part in the process of hyperalgesia
1Ushakova G. A., 1Kornilovska I. N., 1Kobeliatsky Y. Y.
  1. Dnipropetrovsk National University Oles Gonchar
    72, Gagarin Av., Dnipropetrovs'k, Ukraine, 49050

Abstract

It was shown that a hyperalgesia state resulted in the decrease of the mast cell degranulation degree and therefore diminished the amount of free heparin. In-parallel, the augmentation of heparin-binding activity of the rat brain proteins in hemispheres was detected. The morphine or ketamine application 5 min prior to operation preserves the heparin-binding activity of these proteins at the preoperative level

References

[1] Dou CL, Levine JM. Inhibition of neurite growth by the NG2 chondroitin sulfate proteoglycan. J Neurosci. 1994;14(12):7616-28.
[2] Margolis RK, Margolis RU. Nervous tissue proteoglycans. Experientia. 1993;49(5):429-46.
[3] Loeb JA, Fischbach GD. ARIA can be released from extracellular matrix through cleavage of a heparin-binding domain. J Cell Biol. 1995;130(1):127-35.
[4] Margolis RV, Margolis RK, Heparin sulfate and related complex carbohydrates of nervous tissue. Heparin: Structure, Cellular Functions, and Clinical Application. Ed. N. M. McDuffie. New York: Acad, press, 1979: 227-241.
[5] Karlsson J-O, Linde A. Axonal transport of [35S]sulphate in retinal ganglion cells of the rabbit. J Neurochem. 1977;28(2):293-7.
[6] Kuczenski RT, Mandell AJ. Regulatory properties of soluble and particulate rat brain tyrosine hydroxylase. J Biol Chem. 1972;247(10):3114-22.
[7] Brennan TJ, Vandermeulen EP, Gebhart GF. Characterization of a rat model of incisional pain. Pain. 1996;64(3):493-501.
[8] Zimmermann M. Ethical guidelines for investigations of experimental pain in conscious animals. Pain. 1983;16(2):109-10.
[9] Kobelyatskiy YuYu, Ushakova GA. Effect of morphine and ketamine on neuronal and glial ductility postoperative hyperalgesia. Zh Akad Med Nauk Ukrainy. 1999;5(4):732-42.
[10] Dolzhenko MI, Lepekhin EA, Berezin VA. A novel method for evaluation of carbohydrate-binding activity: enzyme-linked carbohydrate-binding assay (ELCBA). Biochem Mol Biol Int. 1994;34(2):261-71.
[11] Limanski? IuP. [Basic principles of the functional organization of the nociceptive and antinociceptive systems of the brain]. Fiziol Zh. 1989;35(2):110-21.
[12] Coderre TJ, Katz J, Vaccarino AL, Melzack R. Contribution of central neuroplasticity to pathological pain: review of clinical and experimental evidence. Pain. 1993;52(3):259-85.
[13] Umarova BA, Shapiro FB, Strukova SM. [Role of catecholamines, released due to stress, on stimulation of heparin secretion by mast cells in rats]. Fiziol Zh. 1993;39(4):52-7.
[14] Withington DE, Patrick JA, Reynolds F. Histamine release by morphine and diamorphine in man. Anaesthesia. 1993;48(1):26-9.
[15] Marone G, Stellato C, Mastronardi P, Mazzarella B. Mechanisms of activation of human mast cells and basophils by general anesthetic drugs. Ann Fr Anesth Reanim. 1993;12(2):116-25.
[16] Della Seta D, de Acetis L, Aloe L, Alleva E. NGF effects on hot plate behaviors in mice. Pharmacol Biochem Behav. 1994;49(3):701-5.
[17] Lewin GR, Rueff A, Mendell LM. Peripheral and central mechanisms of NGF-induced hyperalgesia. Eur J Neurosci. 1994;6(12):1903-12.
[18] Kobiersky MA. Cytokines and inflammation in the central nervous system. Molecular neurobiology of pain. Ed. D. Borsook. New York: Seatle IASP press, 1997; Vol. 9: 45-58.
[19] Kornilovskaya IM. Heteromorphous basophils tissue of rats thyroid. Visn Morfologii. 1995;1:1-3.