Biopolym. Cell. 2001; 17(4):298-301.
Структура и функции биополимеров
Делеция пятого екзона гена bcr/abl при остром лимфобластном лейкозе с филадельфийской хромосомой
1Телегеев Г. Д., 1Дыбков М. В., 1Дубровская А. Н., 1Малюта С. С.
  1. Институт молекулярной биологии и генетики НАН Украины
    ул. Академика Заболотного, 150, Киев, Украина, 03680

Abstract

Секвенирование 3–8 экзонов гибридного гена bcr/abl позволило выявить делецию пятого экзона (108 нуклеотидов) у больного с острым лимфобластным лейкозом с точкой разрыва в M-bcr. Обсуждается возможная роль подобных нарушений в развитии лейкозов с филадельфийской хромосомой.

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