Biopolym. Cell. 1997; 13(1):36-38.
Structure and Function of Biopolymers
Structural-energetic peculiarities of spontaneous examination of canonical nucleotide bases and their modified analogues
1Hovorun D. M.
  1. Institute of Molecular Biology and Genetics, NAS of Ukraine
    150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680

Abstract

By the semiempirical quantum-chemical AMI method there were investigated energetic (enthalpy) and structural (variation in stereochemical non-rigidity and tautomeric state) peculiarities of spontaneous deamination of canonical nucleotide bases and number of their biologically important modified analogues which have exocyclic aminogroup in their composition.

References

[1] Poltev VI, Bruskov VI, Shuliupina NV, Rein R, Shibata M, Ornstein R, Miller J. Genotoxic modification of nucleic acid bases and biological consequences of it. Review and prospects of experimental and computational investigations. Mol Biol (Mosk). 1993;27(4):734-57.
[2] Danilov VI, Kventsel GF. Electronic submission to the theory of point mutations. Kiev: Naukova Dumka, 1971; 83 p.
[3] Remy H. Treatise on Inorganic Chemistry, 1967. Elsevier
[4] Handbook of biochemistry and molecular biology. Ed. G. D. Fasman. Boca Raton: CRC press Inc., 1983; 923 p.
[5] Kondratyuk IV, Govorun DM, Zheltovsky NV. Prototropic molecular-zwitterion tautomerism of xanthine: AMI calculation. Biopolym Cell. 1994; 10(6):52-60.
[6] Hovorun DM, Mishchuk YaR, Kondratyuk IV. On a quantum-chemical nature of a stereochemical nonrigidity of canonical nucleotide bases. Biopolym Cell. 1996; 12(5):5-12.