Biopolymers and Cell. 2011; 27(3): 181-192

INHIBITORS OF LYSOSOMAL CYSTEINE PROTEASES

V. I. Chorna, O. L. Lyanna¹

Dnipropetrovs’k State Agrarian University
25, Voroshylova St., Dnipropetrovs’k, 49600

¹Dnipropetrovs’k State Medical Academy
9, Dzerzhyinskoho St., Dnipropetrovs’k, 49044

    The review is devoted to the inhibitors of cysteine proteinases which are believed to be very important in many biochemical processes of living organisms. They participate in the development and progression of numerous diseases that involve abnormal protein turnover. One of the main regulators of these proteinases is their specific inhibitors: cystatins. The aim of this review was to present current knowledge about endogenous inhibitors of lysosomal cysteine proteases and their synthetic analogs.

Keywords: cystatins, stefins, kininogens, cysteine cathepsins, synthetic inhibitors

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