Biopolymers and Cell. 2011; 27(3): 167-180
BACULOVIRUS VECTORS IN EXPERIMENTAL GENE- AND VACCINE THERAPY
A. P. Solomko, O. A. Zaharuk, L. I. Chaschina, L. I. Strokovskaya
Institute of Molecular Biology and Genetics, NAS of Ukraine
150, Akademika Zabolotnogo St., Kyiv, Ukraine, 03680
The article provides a brief overview of the literature on target design, exploration properties and effectiveness of the application of recombinant baculoviruses in model systems in vivo. The results of experiments with wild and recombinant baculoviruses are analysed in regard to the priority areas of biomedicine such as tissue regeneration, gene therapy of cancer, development of vaccines against infectious diseases and malignancies
Keywords: baculovirus, gene- and immunovector, mammals, system in vivo