Biopolymers and cell. 2010; 26 (6): 441 - 449
Baculovirus integration with the vertebrate cells in system in vitro
A. P. Solomko, O. A. Zaharuk, L. I. Chashchina, L. I. Strokovskaya
Institute of Molecular Biology and Genetics, NAS of Ukraine 150, Academician Zabolotnogo Str., Kyiv, Ukraine, 03680
In this review the literature data are analyzed relative to the study of a new vector system for the cells of vertebrates, based on the insect viruses – baculoviruses. The ways and mechanisms of recombinant baculoviruses penetration into cells, the factors, which influence the effectiveness of transduction, the principles of the modification of virus display, and the reaction of the different types of cells on virus introduction are examined. The prospects of using recombinant baculoviruses in cellular engineering are discussed.
Keywords: baculovirus, vertebrates, interaction, transduction, display, cell response.