Biopolymers and cell. 2009; 25 (2): 142 - 144

Interaction between Hsp60 and Bax in normal human myocardium and in myocardium affected by dilated cardiomyopathy

L. M. Kapustian, O. T. Rozhko, I. O. Tykhonkova, L. L. Sidorik

Institute of molecular biology and genetics NAS of Ukraine 150, Zabolotnogo Str,  Kyiv  Ukraine, 03680

The main functional compartments of molecular chaperone Hsp60 are mitochondria and cytoplasm. Up to 30 % of Hsp60 are located in cytoplasm of cardiomyocytes. The interaction between molecular chaperone Hsp60 and proapoptotic Bax protein in the cytoplasmic fraction from normal human heart tissue has been revealed by co-immunoprecipitation in contrast to myocardium affected by dilated cardiomyopathy, where this interaction has not been observed.

Keywords: Hsp60, Bax, myocardium, dilated cardiomyopathy.