Biopolymers and cell. 2009; 25 (1): 73 - 76

HSP60 gene expression on mRNA level in heart at dilated cardiomyopathy

L. M. Kapustian, O. T. Rozhko, V. I. Bobyk, D. V. Riabenko¹, L. L. Sidorik

Institute of molecular biology and genetics NAS of Ukraine 150, Zabolotnogo Str,  Kyiv  Ukraine, 03680

¹M.D. Strazhesko Institute of cardiology, AMS of Ukraine 5 Narodnogo Opolcheniya str., 03151 Kyiv,Ukraine

The expression of HSP60 gene on mRNA level in the hearts of patients at the terminal stage of dilated cardiomyopathy (DCM) as well as in the hearts of mice with a model disease similar to human DCM has been studied. A significant increase in the HSP60 mRNA level at the early stage and subsequent drop to an initial level at the terminal stage have been shown. At the same time, the Hsp60 protein level was increasing during disease up to the last stage that gives a possibility to suppose the changes in regulation of Hsp60 synthesis or degradation at DCM progression.

Key words: molecular chaperones, Hsp60 gene, mRNA., dilated cardiomyopathy,