Biopolymers and cell. 2008; 24 (5): 406 - 411

Tricyclic 1,2,4-triazine bearing heterosystem: directed synthesis of new bioactive compounds

I. V. Alexeeva, L. G. Palchikovska, L. S. Usenko, V. G. Kostina

A new series of tricyclic heteroaromatic compounds was prepared by cyclization of the 2N-substituted-6-bromo-3-oxo(amino)-1,2,4- triazin-5(4Н)-ones with 2-aminobenzothiol. The structure of bio- active tricyclic glycosides, obtained earlier by the simplified silylic method, is confirmed, as well as expedience and adequacy of this method for directed glycosylation of the triazine bearing tricyclic bases.

Keywords: condensed 1,2,4-triazine, tricyclic nucleoside analogues.