Biopolymers and cell. 2008; 24 (5): 393 - 398

Dynamics of heat shock proteins quantity in rats’ gastric mucosa lysates upon chronic atrophic gastritis development

S. Ya. Mandryk, L. N. Gaida, L. N. Kapustian, I. O. Tykhonkova, О. V. Drobinska, L. L. Sidorik, L. I. Ostapchenko

The levels of Hsp60, Hsp70 and Hsp90 in rats’ gastric mucosa cells lysates upon the development of experimental chronic atrophic gastritis (CAG) were investigated by the immunoblot-analysis. The quantities of Hsp60 and Hsp70 at the early (the first two weeks) and late (the 5–6 th weeks) stages of disease progression were reliably higher in comparison with normal mucosa. It was also observed an increase in Hsp90 expression at the end of the first week of CAG. The increase in Hsp expression in gastric mucosa was shown upon activation of apoptosis, generation of reactive oxygen species, and gastric atrophy development.

Keywords: chronic atrophic gastritis, atrophy, heat shock proteins.