Biopolymers and cell. 2008; 24 (4): 318 - 322

Distribution of FSHR307 and FSHR680 allelic variants of FSH receptor gene exon 10 in females from Ukraine

G. B. Livshyts, S. S. Podlesnaja, S. A. Kravchenko, L. A. Livshits

The purpose of this study was to examine the distribution of two distinct follicle-stimulating hormone receptor (FSHR) variants, Asn680Ser and Thr307Ala, in normaly ovulated group of females from Ukraine. The FSHR gene variants, Asn680Ser and Thr307Ala, were analyzed by PCR and RFLP. The strong linkage disequilibrium between FSHR307 and FSHR680 loci was found (p < 0.0001). The following genotypes have been detected: NN (33.1 %), NS (52.3 %), SS (14.6 %) for Asn680Ser variant and TT (33.1 %), TA (55.4 %), AA (11.5 %) for Thr307Ala variant. Further study on the association of FSHR variant with ovarian dysfunction and individual susceptibility to FSH-stimulation considering our population data would clarify a possible functional role of FSHR307 and FSHR680 loci.

Keywords: FSH receptor gene, polymorphisms, population.