Biopolymers and cell. 2007; 23 (6): 483 - 488

Adhesive proteins in inflammation process

D. D. Zhernossekov

The inflammation process is accompanied by the expression of different adhesive molecules on the surface of both endothelium and blood cells. The adhesion proteins of immunoglobulin, selectin, and integrin family are involved at the certain stages of inflammation response. To cure chronic inflammation processes the selective influence on the molecular mechanism of adhesive interaction of leukocytes is necessary. In the present paper the search for anti-inflammatory anti-adhesive preparations on the basis of structural features of adhesive molecules is discussed.

Keywords: selectins, integrins, Ig-CAM, inflammation.