Biopolymers and cell. 2007; 23 (2): 115 - 121

Experimental model of autoimmune myosin-induced myocardium injury

V. I. Bobyk, D. V. Ryabenko, O. V. Sergienko, I. V. Trunina, O. M. Fedorkova, L. M. Morozova, L. L. Sidorik

Experimental model of autoimmune myosin-induced injury of BALB/c mouse myocardium, similar to human dilated cardiomyopathy (DCM), has been developed. The immunization by myosin, obtained from DCM-affected human heart initiated the following DCM-like myocardial damage: myocytolysis, cardiosclerosis, thinning of left ventricular wall, decrease in cardiac actomyosin ATP-ase activity and increase in anti-myosin autoantibodies level.

Keywords: dilated cardiomyopathy, autoantibodies, myosin, myocardial damage.