Biopolymers and cell. 2007; 23 (1): 14 - 20

Synthesis of 2'-5'-oligoadenylates and study on their effect on proliferation and migration of bone marrow stem cells of mice in vitro and in vivo

Z. Yu. Tkachuk, I. Ya. Dubey, T. G. Yakovenko, L. I. Semernikova, S. O. Shapoval, V. S. Artemenko, L. V. Dubey

2'-5'-Triadenylate and its 3'-epoxy analogue were synthesized by phosphotriester method in solution. These compounds are shown to accelerate the migration of the bone marrow stem cells in donor mice and their inclusion into the spleen of recipient mice upon syngenic transplantation in vivo. 2'-5'-oligoadenylates and their derivatives depending on their structure and concentration influence apoptosis and proliferation of mice bone marrow cells in vitro.

Keywords: 2'-5'-oligoadenylates, migration, oligonucleotide analogues, stem cells, proliferation, apoptosis.