Biopolymers and cell. 2006; 22 (6): 403 - 424

Molecular Biomarkers: New Approaches in Ovarian Cancer Diagnosis

V. V.Gordiyuk, E. V. Simonchuk, E. V. Kohanevitch, G. A. Vakulenko, E.P. Manzhura

The formation of tumors is associated with accumulation of different genetic and epigenetic changes. The current paper summarizes the recent data on molecular markers of human ovarian cancer as well as provides the analysis of the contribution of epigenetic markers for early cancer detection. We examined the significance of changes in signaling pathways in ovarian cancer to identify possible oncomarkers. Monitoring of gene and protein multiple changes has a powerful potential for selection of sets of multiple molecular markers for correct diagnostic and prognostic clinical outcome of ovarian cancer.

Key words: ovarian tumor, early diagnostic of cancer, epigenetic markers, tumor supressor, microchips.