Biopolymers and cell. 2006; 22 (2): 132 - 135

Participation of xanthinoxidase system in oxidative stress development at radiation action

N. G. Raksha, T. R. Andriychuk, M. E. Kucherenko

It has been established, that ionizing radiation of 1.0 Gy dose causes the activation of prooxidant enzyme xanthinoxidase in spleen lymphocytes that is accompanied by enhanced formation of superoxidase anion-radicals and testifies to the participation of xanthinoxidase system in radiation induced cell death. The increase of oxidative modification of proteins in splenocytes of the rat in three hours after total X-irradiation was shown.

Key words: ionizing radiation, xanthinoxidase, anion-radicals, oxidative stress, oxidative modification of proteins.