Biopolymers and cell. 2006; 22 (1): 29 - 32

Eukaryotic elongation factor 1A disintegrates aggregates of phenylalanyl-tRNA synthetase

T. O. Lukash

Translation elongation factor 1A (eEF1A) provides binding and transporting of the appropriate codon-specified aminoacyl-tRNA to the aminoacyl site of the ribosome. Two active tissue-specific isoforms of eEF1A have been identified in mammals. Herewith we report that two isoforms of eEF1A disintegrate the aggregates of phenylalanyl-tRNA synthetase like molecular chaperones which are involved in protein folding and renaturation after stress.

Key words: translation elongation factor 1A, phenylalanyl-tRNA synthetase, chaperone, aggregation, thermodenaturation.