Biopolymers and cell. 2005; 21 (6): 485 - 514

Our shagreen leather is our problem. And we have to solve it. 6. Paying back.

V.A. Kordium

The problem of spatial and temporal organization of metabolic cycles in a cell is being analyzed.  The unsolved questions are emphasized and the variants for their solution are suggested. The total amount of intermediate products as well as their removal from the active centers of metabolic cycle enzymes are being evaluated in view of the ideas  under consideration. The removal of metabolytes is believed to be a result of the macromolecular damage. The age-related changes  are explained  taking into account this suggestion along with peculiarities of the mutative process.

Key words: water in cell, metabolic cycles, chanelling, mutational process, unimportant sequences.