Biopolymers and cell. 2005; 21 (6): 473 - 484

Possible mechanisms of the stability of tumor cells to radial and chemotherapy

V. A. Zinchenko, L. I. Chaschina

The review is devoted to the analysis of the  role chemical and physical factors to creation chemical and radioresistance of tumoral cells. The results of examinations testify that many biological processes, such as modulation of an apoptosis, activation of caspases, amplification of a gene MDR-1 are a basis the creation of fastness to a chemotherapy. Some morphological and biochemical features of development of a secondary radioresistance in tumoral cells are analysed. Some possible ways of overcoming of a secondary radioresistance of the tumor cells surveyed.

Key words: tumoral cell, radioresistance, chemoresistance, P-glycoprotein, apoptosis.