Biopolymers and cell. 2005; 21 (3): 220 - 229

Tumor-associated antigens and development of immunotherapeutics strategies

R. G. Kyyamova, V. V. Filonenko

The tumor-associated antigens, up-to-date methods for their identification and immunotherapeutics strategies for cancer treatment have been reviewed. The main attention has been focused on the antigens identified by SEREX (Serological identification of antigens by recombinant expression cloning) methodology and the categories of tumor-associated antigens (i. e. identified by SEREX approach) have been listed. The main immunotherapeutic approaches have been classified, the successes of active specific immunotherapy based on immunodominant peptides of tumor-associated antigens have been described.

Key words: immunotherapy, antigen, cancer.