Biopolymers and cell. 2005; 21 (1): 64 - 69

Nonlinear kinetics of tumor volumes and spatial chaos of sarcoma 45 cell shapes after the treatment by mechanically modified doxorubicin, 40 MHz irradiation and their combination

V. A. Zinchenko, V. E. Orel, Yu. A. Belov, N. M. Dzyatkovskaya, M. I. Danko, A. V. Romanov, O. B. Morozov, O. Yu. Pridatko

The characteristic features of malignant tumors may be the peculiarities of the nonlinear growth dynamics and atypical cell shapes, which can be qualitatively estimated on the basis of a deterministic chaos conception. The comparative study of nonlinear kinetics of tumor volumes change, spatial chaos of cell shapes and cytological changes of cells in animals with sarcoma-45 under the influence of 40 MHz electromagnetic irradiation (EI), anticancer anthracycline antibiotic officinal doxorubicin (DR) and mechanochemically activated (MA) DR and their combination was undertaken. The kinetics of sarcoma-45 tumor volumes change in control animals (without any treatment) was the most nonlinear, while after the combined action of EI and MA DR the nonlinearity was minimal. The shapes of tumor cells in control animals as well as of the cells mostly affected by MA DR and EI action have the greatest spatial chaos. Possibly it is a result of changes in deterministic molecular chaos in tumor cells under chemical treatment with MA DR and EI.

Key words: cells of sarcoma-45, doxorubicin, electromagnetic irradiation, chaos