Biopolymers and cell. Volume 20. № 6. 472-478.

N. V. Litvinova, T. N. Kurapova

The nonsteroidal anti-inflammatory drugs: possible mechanisms of antioxidant action

Summary

The nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used in medicine for their anti-inflammatory, antipyretic and analgesic properties. The inhibition of prostaglandine synthase is the main mechanism responsible for the anti-inflammatory action of NSAIDs and to some extent - for their antioxidant properties. Some other probable mechanisms of antioxidant action of NSAIDs have been discussed in this article, namely: antiradical activity of the compounds; their capability to increase the activity of anti<->oxidants enzymes, such as superoxide dismutase (SOD), glutathione peroxidase (GSP), glutathione-S-transferase (GST); influence on transport properties of blood serum albumin; ability to stabilize the structure of biomembranes; to prevent diffusion of oxygen, catalysts and activators of lipids peroxidation into hydrophobic sites of the membranes. Mechanisms of realization of antioxidant action of NSAIDs are considered to be individual for each compound and mainly dependent on the chemical structure.